Lysophosphatidic acid stimulates prostaglandin E2 production in cultured stromal endometrial cells through LPA1
M2 PHARMA-May 30, 2018-Epigen Biosciences Licenses LPA1
Receptor to Novo Nordisk
According to the contract, Novo Nordisk has licensed the LPA1
receptor antagonist EPGN696 for development in diabetic and chronic kidney disease and other chronic diseases associated with metabolic syndrome.
Cholesterol was reported to participate in the endocytosis of lysophosphatidic acid-related receptors (LPA1
) because the formation of LPA1-ARRBs is dependent on membrane cholesterol .
This receptor has 52% and 48% homology with LPA1
and LPA2, respectively, and is located on Chr1p22.3-p31.1 [30, 38, 39].
Vazquez-Tello et al., "Intracrine signaling through lipid mediators and their cognate nuclear G-protein-coupled receptors: a paradigm based on PGE2, PAF, and LPA1
receptors," Canadian Journal of Physiology and Pharmacology, vol.
Global Markets Direct's, 'Lysophosphatidic Acid Receptor 1 (Lysophosphatidic Acid Receptor Edg-2 or LPAR1 or EDG2 or LPA1
) - Pipeline Review, H1 2016', provides in depth analysis on Lysophosphatidic Acid Receptor 1 (Lysophosphatidic Acid Receptor Edg-2 or LPAR1 or EDG2 or LPA1
) targeted pipeline therapeutics.
En razon a lo anterior, para el primer modelo, correspondiente a la linea de produccion artesanal de la marroquineria del cuero y repujado (Marroquineria LPA1
), se puede decir que ser jefe de hogar artesano tiene una probabilidad de 9,8% de pertenecer a la LPA1
, en comparacion con aquellos que no son jefes de hogar.
The data also indicate that subtype H5N1 viruses have not reassorted with low pathogenic avian influenza (LPA1
) viruses since their initial introduction (online Technical Appendix 2 Figure 1).
Deletion of lysophosphatidic acid receptor LPA1
reduces neurogenesis in the mouse dentate gyrus.
To investigate how LPA exerted this effect, the team produced mice that genetically lack one or both of the two receptors -- LPA1
and LPA2 -- to which LPA can bind on ventricle-building fetal progenitor cells, finding that the LPA1
receptor was required to produce hydrocephalus.
(69) The G protein-coupled receptors for lysophosphatidic acid, LPA1
and LPA2, which can signal through nuclear factor [kappa]B or Akt, were recently shown by Yamada et al (70) to be expressed in MPM cell lines and human samples, and the addition of LPA enhanced cell proliferation and motility via LPA1
and LPA2, respectively.