OLR1

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OLR1

A gene on chromosome 12p13.2-p12.3 that encodes a C-type lectin domain receptor which mediates the recognition, internalisation and degradation of oxidatively modified low-density lipoprotein (oxLDL) by vascular endothelial cells. It is also a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria, as well as for HSP70 protein, which is involved in antigen cross-presentation to naïve T-cells. OLR1 is also involved in inflammation, acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation.
References in periodicals archive ?
Nevertheless, the LOX1 gene had its highest expression level in the NaCl200 control, which was reduced by 1.
Of the investigated salt stress genes in tomato plants, the AIM1, AGP-S1, APX2, LOX1 and MAPK2 genes were expressed only under NaCl stress, and they were not expressed in non-treated plants.
AIM1, LOX1 and NHX6, is up-regulated by AgNPs under NaCl150 stress whereas they are down-regulated under NaCl200 stress.
Slides were incubated in a humidified chamber for 1 h at room temperature with primary antibody: EGFR (RM-2111-S0, dilution 1:50, Thermo Scientific), p53 (M3629, dilution: 1:100, DAKO GmbH, Hamburg, Germany), (RM-2111-S0, dilution 1:50, Thermo Scientific), c-Myc (MS-139-PCL, dilution 1:50, Thermo Scientific), Ki67 (abl6667, dilution 1:100, Abeam, Cambridge, UK), CD31 (MS353-S0, dilution 1:50, Thermo Scientific), P-glycoprotein (CD243, AM05632PU-N, dilution 1:200, Acris, Herford, Germany), GSTP1 (AP02100SU-S, Acris), COX2 (AMU127PU-N, dilution 1:100, Acris), LOX1 (HPA050798, dilution 1:300, Sigma), TFR (CD71; MS-1096S0, dilution 1:50, Thermo Scientific), and VEGF (Ab-7, clone VG-1, which recognized 121,165, and 189 isoformes of VEGF; dilution 1:150, Thermo Scientific).
Quantification of immunostained slides revealed the highest values for COX2, EGFR, MYC, LOX1, and TFR, whereas P-glycoprotein and p53 expression was lowest.
6) and the microarray-based expression values of 11 tumor markers (ABCB1, CSTP1, COX2, LOX1, EGFR, MYC, K167, TFR, VECFA, VEGFB, VEGFC) of PC-3 and DU-145 prostate cancer cells have been deposited in the database of the National Cancer Institute (NCI, USA).
LOX1, MYC, TFRC and VEGFC expression most frequently high in cluster 2.
A possible role of the inflammation marker LOX1 is new and has not been described as of yet.
Abbreviations: COX2, cyclooxygenase 2; CRP, C-reactive protein; EGFR, epidermal growth factor receptor; GSTP1, glutathione S-transferase PI; LOX1, oxidized low density lipoprotein (lectin-like) receptor 1, MRT, magnetic resonance tomography; PSA, prostate-specific antigen, SPECT, single-photon emission computed tomography; TFR, transferrin receptor (CD71); VEGF, vascular endothelial growth factor.
These lesions are attributed to a reduction in elasticity of cardiac blood vessels in response to a decrease in LOX1 activity.
Increased vascular LOX1 activity in hypertensive rats (Ooshima and Midorikawa, 1977) and increased LOXL1 expression in right ventricle of steer with pulmonary hypertension (Han et al.