OLR1

(redirected from LOX1)

OLR1

A gene on chromosome 12p13.2-p12.3 that encodes a C-type lectin domain receptor which mediates the recognition, internalisation and degradation of oxidatively modified low-density lipoprotein (oxLDL) by vascular endothelial cells. It is also a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria, as well as for HSP70 protein, which is involved in antigen cross-presentation to naïve T-cells. OLR1 is also involved in inflammation, acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The oxidized low-density lipoprotein receptor 1 (OLR1), also known as LOX1, is a type-II membrane cell-surface protein [4], that plays an important role in the degradation of oxidized low-density lipoprotein (Ox-LDL) and adipocyte proliferation [5].
The current study was planned to investigate whether LOX-1 is implicated in oxLDL-induced up-regulation of TF and whether P.rbeta2-GPI DV inhibits the binding of oxLDL to LOX1, and, accordingly, inhibits TF expression.
Bu farklilasmis makrofajlar, LOX1, SAR ve CD36 gibi reseptorlerin ekspresyonun artmasi sonucu LDL'yi tanir ve fagosite ederler.
Previous study found that oxidized-low density lipoprotein (ox-LDL) and oxidative stress induce production of lectin-like oxidized low density lipoprotein receptor-1 (LOX1) and cleavage some extracellular parts of LOX-1 into blood circulation, and it is called soluble LOX-1 (sLOX-1) [10].
AGE = advanced glycation end-products; LDL = low-density lipoprotein; FFA = free fatty acids; ER = endoplasmic reticulum; PI3K = phosphatidylinositol-3-kinase; LOX1 = oxidized LDL receptor 1; RAGE = receptor for advanced glycation end-products; TLR4 = Toll-like receptor 4.
For instance, transfection of let-7g into VSMCs has been shown to significantly inhibit VSMCs proliferation and migration induced by ox-LDL by targeting LOX1 [104].
Studies have shown that LOX1 is expressed in macrophages among other cells but can also be stimulated in a variety of cell types using TNF-[alpha], PMA, and shear stress [3].
Linoleate 9S-lipoxygenase B (LOX1) was not expressed in non-treated control plants and had high expression in tomato plants with both NaCl stress and AgNP treatments.
Slides were incubated in a humidified chamber for 1 h at room temperature with primary antibody: EGFR (RM-2111-S0, dilution 1:50, Thermo Scientific), p53 (M3629, dilution: 1:100, DAKO GmbH, Hamburg, Germany), (RM-2111-S0, dilution 1:50, Thermo Scientific), c-Myc (MS-139-PCL, dilution 1:50, Thermo Scientific), Ki67 (abl6667, dilution 1:100, Abeam, Cambridge, UK), CD31 (MS353-S0, dilution 1:50, Thermo Scientific), P-glycoprotein (CD243, AM05632PU-N, dilution 1:200, Acris, Herford, Germany), GSTP1 (AP02100SU-S, Acris), COX2 (AMU127PU-N, dilution 1:100, Acris), LOX1 (HPA050798, dilution 1:300, Sigma), TFR (CD71; MS-1096S0, dilution 1:50, Thermo Scientific), and VEGF (Ab-7, clone VG-1, which recognized 121,165, and 189 isoformes of VEGF; dilution 1:150, Thermo Scientific).
Novelli, "Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX1): a critical player in the development of atherosclerosis and related disorders," Cardiovascular Research, vol.