OLR1

(redirected from LOX-1)

OLR1

A gene on chromosome 12p13.2-p12.3 that encodes a C-type lectin domain receptor which mediates the recognition, internalisation and degradation of oxidatively modified low-density lipoprotein (oxLDL) by vascular endothelial cells. It is also a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria, as well as for HSP70 protein, which is involved in antigen cross-presentation to naïve T-cells. OLR1 is also involved in inflammation, acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation.
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References in periodicals archive ?
7,8 OxLDL can bind to lectin-like oxidised LDL receptor (LOX-1), one of the scavenger receptors expressed in macrophages, to activate signalling pathways involved in the pathogenesis of atherosclerosis.
Previous study found that oxidized-low density lipoprotein (ox-LDL) and oxidative stress induce production of lectin-like oxidized low density lipoprotein receptor-1 (LOX1) and cleavage some extracellular parts of LOX-1 into blood circulation, and it is called soluble LOX-1 (sLOX-1) [10].
Pattern recognition receptors (PRRs), including toll-like receptor 2 (TLR2) [8, 9], toll-like receptor 4 (TLR4) [10, 11], lectin-type oxidized LDL receptor 1 (LOX-1) [11, 12], and dendritic cell-associated c-type lectin-1 (dectin-1) [10, 13], each play an important role in antifungal immunity.
Accumulation of cholesterol esters in macrophages is a hallmark of foam cell formation that depends on the uptake of oxidized low-density lipoprotein (ox-LDL) via its receptors, lectin-like ox-LDL receptor-1 (Lox-1) and CD36, and on the efflux of free cholesterol by ATP-binding cassette transporter A1 (ABCA1) and ATP-binding cassette subfamily G member 1 (ABCG1) [8].
Previous research suggests the importance of the lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) [1, 3].
LOX-1, the major endothelial oxidized low-density lipoprotein (oxLDL) receptor-1 [1], is undetectable under healthy conditions but is highly expressed in atherogenic settings and atherosclerotic lesions [2].
OxLDL acts via binding to several SRs, including SR-A, SR-BI, CD36, and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) [3].
LOX-1, lectin-type oxidized LDL receptor 1, was originally identified as a receptor for atherogenic oxidized LDL in vascular endothelial cells (14).
Aortic LOX-1 (lectin-like oxidized low-density lipoprotein receptor-1) mRNA and protein increased after ozone exposure, and LOX-1 protein increased after exposure to ozone + DEP.
A recent study from our group showed that LOX-1, a receptor of ox-LDL, is highly expressed in bmMSCs, and its activation by ox-LDL stimulates proliferation of bmMSCs [1].