7,8 OxLDL can bind to lectin-like oxidised LDL receptor (LOX-1
), one of the scavenger receptors expressed in macrophages, to activate signalling pathways involved in the pathogenesis of atherosclerosis.
Previous study found that oxidized-low density lipoprotein (ox-LDL) and oxidative stress induce production of lectin-like oxidized low density lipoprotein receptor-1 (LOX1) and cleavage some extracellular parts of LOX-1
into blood circulation, and it is called soluble LOX-1
Pattern recognition receptors (PRRs), including toll-like receptor 2 (TLR2) [8, 9], toll-like receptor 4 (TLR4) [10, 11], lectin-type oxidized LDL receptor 1 (LOX-1
) [11, 12], and dendritic cell-associated c-type lectin-1 (dectin-1) [10, 13], each play an important role in antifungal immunity.
Accumulation of cholesterol esters in macrophages is a hallmark of foam cell formation that depends on the uptake of oxidized low-density lipoprotein (ox-LDL) via its receptors, lectin-like ox-LDL receptor-1 (Lox-1
) and CD36, and on the efflux of free cholesterol by ATP-binding cassette transporter A1 (ABCA1) and ATP-binding cassette subfamily G member 1 (ABCG1) .
Previous research suggests the importance of the lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1
) [1, 3].
, the major endothelial oxidized low-density lipoprotein (oxLDL) receptor-1 , is undetectable under healthy conditions but is highly expressed in atherogenic settings and atherosclerotic lesions .
Three isozymes, LOX-1
, LOX-2 and LOX-3, were found in rice embryos on a DEAE-Sephacel Column; LOX-3 and LOX-2 were the major components, and LOX-1
is too scant to be purified by Sephadex G-150 chromatography (Ida et al., 1983).
Keywords: Ginkgo biloba Atherosclerosis Activated platelets ROS LOX-1
OxLDL acts via binding to several SRs, including SR-A, SR-BI, CD36, and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1
, lectin-type oxidized LDL receptor 1, was originally identified as a receptor for atherogenic oxidized LDL in vascular endothelial cells (14).
(lectin-like oxidized low-density lipoprotein receptor-1) mRNA and protein increased after ozone exposure, and LOX-1
protein increased after exposure to ozone + DEP.
A recent study from our group showed that LOX-1
, a receptor of ox-LDL, is highly expressed in bmMSCs, and its activation by ox-LDL stimulates proliferation of bmMSCs .