SIK2(redirected from LOH11CR1I)
SIK2A gene on chromosome 11q23.1 that encodes a kinase which phosphorylates IRS1 in insulin-stimulated adipocytes, modulating the efficiency of insulin signal transduction. SIK2 also inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
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