ALOX5

(redirected from LOG5)

ALOX5

A gene on chromosome 10q11.2 that encodes a member of the lipoxygenase (LOX) family of non-heme iron dioxygenases, which are involved in the production and metabolism of fatty acid hydroperoxidases.

Molecular pathology
Mutations in the ALOX5 promoter region lead to a reduced response to antileukotriene drugs used for asthma, and may also be linked to atherosclerosis and several cancers.
Mentioned in ?
References in periodicals archive ?
The original 1994 experiment consisted of treatments LOGO (lime 0 t [ha.sup.-1] and gypsum 0 t [ha.sup.-1]), L0G1, L0G2.5, LOG5, LIG0, L2.5G0, L5G0, L1G1 and L2.5G1.
Undisturbed core samples (90 by 75 mm) were taken from 2 depths (0-75 and 150-225 mm) from LoG5, LSG0, L2.5G 1, and L0G0 plots (DD and RT) for soil moisture characteristic determination.
Problem Original RIFO Strong log1 571/25 (13 -- log2 502/21 (20) -- log3 958/26 (27) -- log4 3561/42 (w) 189/30 (--) log5 4985/53 (w) 119/26 (31) mprime1 7809/36 (5) 7/9 ([perpendicular to]) mprime2 3281/32 (8) -- mprime3 97259/68 (--) -- mprime4 8485/42 (5) 7/10 (4) mprime5 6773/22 (6) -- grid1 2610/38 (14) -- grid2 4501/50 (--) 69/19 ([perpendicular to]) grid3 7256/64 (--) 315/21 ([perpendicular to]) grid4 11151/80 (--) 135/24 (47) grid5 16240/98 (--) 1481/49(--) Problem RIFO Weak log1 -- log2 -- log3 -- log4 -- log5 -- mprime1 11/9 ([perpendicular to]) mprime2 -- mprime3 -- mprime4 -- mprime5 -- grid1 80/11 (20) grid2 260/19 (31) grid3 557/21 (--) grid4 -- grid5 -- It also shows the number of selected ground actions and objects after the stronger and weaker RIFO pruning processes.
His formula for estimating the probability that team X beats team Y, which James referred to as the log5 method, is given by the following equation:
Later in The Bill James Baseball Abstract of 1983, James extended the log5 method to individual player matchups.
(3) As it is presented in James' Abstracts, however, the log5 method can only estimate the probabilities for a sample space which contains two events--in the above examples, team X either wins or loses and a hit either occurs or does not.
By examining Equation (2) we can see how this extension of the log5 method might be accomplished.
We will now show that the log5 method is a special case of our derived formula.
Using the home-and-away winning percentages, I calculated each team's probability of winning at home and away using a variation of the log5 method.
To account for this, a technical adjustment needs to be made to each team's actual winning percentages before applying log5. Interested readers can see Table 5 for the adjustment, and a full explanation can be found in SABR's By the Numbers.
(10.) Ciccolella, Ray, "Log5: Derivations and Tests", By the Numbers, August 2004.
(12.) Ciccolella's procedure reduces the log5 probability error by a factor of nearly 200.