LMX1 | definition of LMX1 by Medical dictionary
LMX1A (redirected from LMX1)
LMX1A A gene on chromosome 1q24.1 that encodes a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin. LMX1A activates transcription by binding to an A/T-rich sequence—the FLAT element—in the insulin gene promoter; it is involved in the development of the roof plate and specifies dorsal cell fates in the CNS and developing vertebrae.
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References in periodicals archive
LINE-1, HS3ST2, CCNA1, EPB41L3, EDNRB, LMX1
, and DPYS were hypermethylated in cervical cancer tissues, CIN III and CIN II, versus normal tissues and CIN I, of which EPB41L3 seems to be the best marker.
This gene induces expression of the transcription factor LMX1
in the dorsal mesenchyme, specifying these cells as dorsal.
I am very confident in the decisions that my LMX2 supervisor(s) makes.