LMP-1


Also found in: Acronyms.

LMP-1

A 60-kD transmembrane protein encoded by the BNLF1 gene of Epstein-Barr virus, which is essential for EBV-mediated growth transformation. It mediates cell signaling by the TNF-alpha/CD40 pathway.

Detected by PCR, Southern blot, in situ hybridization.

Abnormal expression
Infectious mononucleosis, atypical lymphoproliferations, AIDS-related lymphomas, peripheral T-cell lymphomas, anaplastic (Ki-1-positive) large cell lymphomas, Hodgkin lymphoma (specifically, in Reed-Sternberg cells), and in undifferentiated nasopharyngeal carcinoma.
References in periodicals archive ?
La proteina viral LMP-1 que expresan los linfomas en humanos se ha correlacionado con un pronostico agresivo y con metastasis rapida a otros tejidos linfaticos (Lara-Torres 2009; Hu et al.
Control positivo de LMP-1: se observa una coloracion rojiza en el citoplasma celular (40x).
In the North Indian study the MC subtype (72.4%) was much higher than NS (22.7%) but both showed identical EBV positivity (97%).11 In contrast to this in a South Indian study EBV LMP-1 showed more positivity in the NS subtype, 86% cases.19
In the Middle East in Jordan where the NS constituted 70% of all HL in a study, the maximum positivity was found in MC subtype (80.7%) as compared to NS (30.3%).18 Similarly in a study of EBV associated HL in Cairo, Egypt, the NS subtype constituted 84% but showed EBV positivity for 60% in contrast to MC constituting 9% with 100% EBV positivity.20 In Iraq MC subtype (42%) dominated NS (22%) but again the MC was 100% positive for EBV LMP-1 as compared to 90.9% positivity for NS.21 In the Iran NS (66%) dominated over MC (31%) but LMP-1 was positive in 46.7% cases of MC as compared to 15.4% of NS and the difference was statistically significant.22
In an Austrian study NS was the most common subtype with 59% cases, followed by 31% cases of MC subtype but the EBV positivity by LMP-1 immuno-reactivity was detected in 21% of the NS subtype and 38% of the MC subtype.17 In Latin America in a retrospective study of EBV associated HL among children in Argentina, MC subtype showed 76% positivity whereas all cases of NS were negative.
(13), yaslari 4-32 arasindaki 50 hastanin adenoid ve tonsil dokularinda immunohistokimyasal yontem ile EBV LMP-1 'i %14, EBNA 2 yi %6, insitu hibridizasyon yontemiyle ise EBV LMP-1'i %8, EBNA-2'yi %8 pozitif, saptamislardir.
Bu iliskiyi doku duzeyinde gosteremesek de EBV LMP-1 pozitif olgularda evre 3-4 orani, negatif olgulardan yuksek bulundu.
Among EBERs and LMP-1 positive cases, there were 5 immunocompromised patients, either with HIV infection or with primary immunodeficiency (Table 2).
Treatment results and outcome of children with NHL were correlated with the histologic subtype, EBERs in situ hybridization, and LMP-1 expression.
The results of this study indicate that the distribution of EBV within our sample of cases of pediatric NHL shows EBERs presence and LMP-1 expression in 25% of patients.