LMNB1

LMNB1

A gene on chromosome 5q23.2 that encodes lamin B1, a protein highly conserved in evolution that forms part of the two-dimensional matrix of proteins located next to the inner nuclear membrane. Lamins are involved in providing nuclear stability and chromatin structure, and in gene expression.

Molecular pathology
LMNB1 mutations cause autosomal dominant adult-onset leukodystrophy (ADLD).
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Homozygous Lmnb1 mutant mice survived embryonic development but died at birth with defective organogenesis of the lung and bone [4].
NAFLD&NASH to HCC PBC&PSC to HCC The highly activated ACTA2, AIFM1, APP, ACTB, ADRB2, APP, network biomarkers EGFR, GRB2, NEDD8, CSNK2A1, EGFR, for potential SHC1, TUBA1C, TUBB6, HUWE1, LMNB1, PCK1, inhibition strategy IL4R, GPR37, FRAT2, PPP2CA, SMAD5, of drug design HIST2H2BE, HSPB1, TSC22D1, ESR1, PGR, ZNF480, TIMP1, RYR2, FRAT2, ALDOB, ZYX, YBX1, HIST2H2BE, ZNF480, TP53, STAT5A, AR, H3F3A, TIMP1, ALDOB, TELO2, PXN, TBP, IGF2, AR, TP53, SRF, REPIN1, HSF1, ETS1, NRF1, STAT5A, STUB1, RFC5, RPL30, RPL23A, SP1, SP3, TRMT1, GSK3B, UBC, CEBPA, BPTF, ETS1, ALB, and MIR21 MDC1, RFC5, RPL30, TRMT1, UBC, GSK3B, TF, and MIR21 The repressed ALK and GATA1 CEBPE and GATA1 network biomarkers for potential activation strategy of drug design
In this study, it was found that peptidylprolyl isomerase A (PPIA), similar to peptidylprolyl isomerase A isoform 1 (LOC654188), transgelin 2 (TAGLN2), and isoform long of 14-3-3 protein beta/alpha (YWHAB) were downregulated, and lamin B1 (LMNB1), Annexin A2 (ANXA2), and Annexin A2-like protein (ANXA2P2) were upregulated in low versus high BMD subjects [40].
Finally, lamin B1 (LMNB1), a matrix protein involved in cytoskeletal organization and adipogenesis (Verstraeten et al.
The panel includes seven genes (ANXA3, CLEC4D, LMNB1, PRRG4, TNFAIP6, VNN1, and IL2RB) and is tested on RNA extracted from peripheral blood [86].
Malhas et al., "Is LMNB1 a susceptibility gene for neural tube defects in humans?" Birth Defects Research A--Clinical and Molecular Teratology, vol.
The downregulated transcripts included only two genes of known function that were downregulated by more than 4fold: lamin B1 (LMNB1, a structural factor) and tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 (TNKS2, an enzyme activator).
Ser23 of Lamin B1 (LMNB1) was also identified as an upregulated phosphosite in the resistant cell lines in this study.
The LMNA gene encodes A-type lamins, whereas the B-type lamins, Bl B2, and 83, are encoded by the LMNB1 and LMNB2 genes (Goldman et al.
(35) Identification of a tandem genomic duplication resulting in a copy of the gene encoding the nuclear lamina protein lamin B1 (LMNB1) was made in 2006.
Preliminary research indentified six genes (ANXA3, CLEC4D, LMNB1, PRPG4, VNN1, and IL2RB) whose expression could meaningfully discriminate between blood samples provided by 116 patients with colorectal cancer and 127 control subjects.