LMNB1

A gene on chromosome 5q23.2 that encodes lamin B1, a protein highly conserved in evolution that forms part of the two-dimensional matrix of proteins located next to the inner nuclear membrane. Lamins are involved in providing nuclear stability and chromatin structure, and in gene expression.

Molecular pathology
LMNB1 mutations cause autosomal dominant adult-onset leukodystrophy (ADLD).

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Homozygous Lmnb1 mutant mice survived embryonic development but died at birth with defective organogenesis of the lung and bone [4].

Differential Expression of LaminB1 in the Developing Rat Cochlea

NAFLD&NASH to HCC PBC&PSC to HCC The highly activated ACTA2, AIFM1, APP, ACTB, ADRB2, APP, network biomarkers EGFR, GRB2, NEDD8, CSNK2A1, EGFR, for potential SHC1, TUBA1C, TUBB6, HUWE1, LMNB1, PCK1, inhibition strategy IL4R, GPR37, FRAT2, PPP2CA, SMAD5, of drug design HIST2H2BE, HSPB1, TSC22D1, ESR1, PGR, ZNF480, TIMP1, RYR2, FRAT2, ALDOB, ZYX, YBX1, HIST2H2BE, ZNF480, TP53, STAT5A, AR, H3F3A, TIMP1, ALDOB, TELO2, PXN, TBP, IGF2, AR, TP53, SRF, REPIN1, HSF1, ETS1, NRF1, STAT5A, STUB1, RFC5, RPL30, RPL23A, SP1, SP3, TRMT1, GSK3B, UBC, CEBPA, BPTF, ETS1, ALB, and MIR21 MDC1, RFC5, RPL30, TRMT1, UBC, GSK3B, TF, and MIR21 The repressed ALK and GATA1 CEBPE and GATA1 network biomarkers for potential activation strategy of drug design

Investigating Pathogenic and Hepatocarcinogenic Mechanisms from Normal Liver to HCC by Constructing Genetic and Epigenetic Networks via Big Genetic and Epigenetic Data Mining and Genome-Wide NGS Data Identification

In this study, it was found that peptidylprolyl isomerase A (PPIA), similar to peptidylprolyl isomerase A isoform 1 (LOC654188), transgelin 2 (TAGLN2), and isoform long of 14-3-3 protein beta/alpha (YWHAB) were downregulated, and lamin B1 (LMNB1), Annexin A2 (ANXA2), and Annexin A2-like protein (ANXA2P2) were upregulated in low versus high BMD subjects [40].

"Omics" Signatures in Peripheral Monocytes from Women with Low BMD Condition

Finally, lamin B1 (LMNB1), a matrix protein involved in cytoskeletal organization and adipogenesis (Verstraeten et al.

Adipogenic Effects and Gene Expression Profiling of Firemaster[R] 550 Components in Human Primary Preadipocytes

The panel includes seven genes (ANXA3, CLEC4D, LMNB1, PRRG4, TNFAIP6, VNN1, and IL2RB) and is tested on RNA extracted from peripheral blood [86].

Colorectal Cancer Blood-Based Biomarkers

Malhas et al., "Is LMNB1 a susceptibility gene for neural tube defects in humans?" Birth Defects Research A--Clinical and Molecular Teratology, vol.

Spina Bifida: Pathogenesis, Mechanisms, and Genes in Mice and Humans

Anti-[beta]-actin or LMNB1 monoclonal antibody was used as loading control.

Astragalus polysaccharide protects astrocytes from being infected by HSV-1 through TLR3/NK-[kappa]B signaling pathway

The downregulated transcripts included only two genes of known function that were downregulated by more than 4fold: lamin B1 (LMNB1, a structural factor) and tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 (TNKS2, an enzyme activator).

Gene expression profiling of the paracrine effects of uterine natural killer cells on human endometrial epithelial cells

Ser23 of Lamin B1 (LMNB1) was also identified as an upregulated phosphosite in the resistant cell lines in this study.

Combined phosphoproteomics and bioinformatics strategy in deciphering drug resistant related pathways in triple negative breast cancer

The LMNA gene encodes A-type lamins, whereas the B-type lamins, Bl B2, and 83, are encoded by the LMNB1 and LMNB2 genes (Goldman et al.

[beta]-Asarone induces senescence in colorectal cancer cells by inducing lamin B1 expression

(35) Identification of a tandem genomic duplication resulting in a copy of the gene encoding the nuclear lamina protein lamin B1 (LMNB1) was made in 2006.

Magnetic resonance findings in leucodystrophies and MS

Preliminary research indentified six genes (ANXA3, CLEC4D, LMNB1, PRPG4, VNN1, and IL2RB) whose expression could meaningfully discriminate between blood samples provided by 116 patients with colorectal cancer and 127 control subjects.

Six-gene cluster stratifies need for colonoscopy

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