LMNB1

LMNB1

A gene on chromosome 5q23.2 that encodes lamin B1, a protein highly conserved in evolution that forms part of the two-dimensional matrix of proteins located next to the inner nuclear membrane. Lamins are involved in providing nuclear stability and chromatin structure, and in gene expression.

Molecular pathology
LMNB1 mutations cause autosomal dominant adult-onset leukodystrophy (ADLD).
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The LMNA gene encodes A-type lamins, whereas the B-type lamins, Bl B2, and 83, are encoded by the LMNB1 and LMNB2 genes (Goldman et al.
[beta]-Asarone induces senescence in colorectal cancer cells by inducing lamin B1 expression
45,46) Both GFAP and LMNB1 are members of the intermediate filament superfamily.
Magnetic resonance findings in leucodystrophies and MS
Preliminary research indentified six genes (ANXA3, CLEC4D, LMNB1, PRPG4, VNN1, and IL2RB) whose expression could meaningfully discriminate between blood samples provided by 116 patients with colorectal cancer and 127 control subjects.
Six-gene cluster stratifies need for colonoscopy
Preliminary research identified six genes (ANXA3, CLEC4D, LMNB1, PRRG4, VNN1, and 1L2RB) whose expression could meaningfully discriminate between blood samples provided by 116 patients with colorectal cancer and 127 control subjects.
Gene cluster stratifies colonoscopy candidates: Canadian company will offer laboratory-based blood screening for six marker genes in colorectal cancer
Lamins A and C are splice variants of a single lamin A (LMNA) gene, whereas lamins B1 and B2 are encoded by two separate LMNB1 and LMNB2 genes.
Lamin polymerization: a regulatory process for programmed cell survival

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