LKB1 and AMP-activated protein kinase control of mTOR signalling and growth.
Some oncogenes in lung cancers (alteration in TP53, K EGFR, RAS, CDKN2, FHIT, MYC,
LKB1 and RB genes) are shown to affect tumor microenvironment to promote immune escape (14).
Bu sistemle olusturulan bir diger oldukca favori olan model ise
Lkb1:LSLK-RasG12D' dir ve insan metastazina oldukca benzer adenokarsinomlar ve skuamoz hucre karsinomlari gelisir (52).
Loss of
Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression.
The
LKB1 tumor suppressor negatively regulates mTOR signaling.
The CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by
LKB1 loss.
The cause of PJS is a mutant gene named STK1, also known as
LKB1. This gene is localized at 19p34-p36 and is a serine/threonine kinase that controls growth regulation.
Both these molecules affect similar biological process and it has also been discovered that Sirt1 phosphorylates
LKB1, the upstream kinase of AMPK and AMPK activated Sirt1 though Nampt (Cetrullo et al., 2015) AMPK is a serine threonine kinase which acts as a metabolic fuel gauge.
Studies have shown that NUCB2/Nesfatin-1 can promote colon cancer cell migration, invasion, and epithelial-mesenchymal transition through
LKB1, AMPK/TORC1/ZEB pathways.[17] A study by Yoo et al.
AMPK promotes its phosphorylation [24] at the Thr172 residue in its a subunit [25] by using an upstream kinase that was identified as a complex between tumor suppressor protein
LKB1 and two accessory subunits STRAD and MO25 [26].
AMP competes with ATP for binding to the y regulatory subunit of AMPK [177, 178] and by doing so, greatly increases AMPK activity, but only in the presence of an upstream kinase such as liver kinase B1 (
LKB1) [179].
Vasquez et al., "Medicine: the kinase
LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin," Science, vol.