STK11

(redirected from LKB1)

STK11

A gene on chromosome 19p13.3 that encodes a ubiquitously expressed serine/threonine-protein kinase which controls the activity of AMP-activated protein kinase (AMPK) family members, playing a role in various cellular processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. STK11 acts by phosphorylating the T-loop of AMPK family proteins, upregulating their activity.

Molecular pathology
Defects in STK11 are a cause of Peutz-Jeghers syndrome; it has been linked to testicular germ cell tumours and sporadically to non-small cell carcinomas of the lung. Defects in STK11 also promote carcinogenesis, including lung cancer progression and metastasis, and confers in lung adenocarcinoma the ability to trans-differentiate into squamous cell carcinoma.
References in periodicals archive ?
This two-and-a-half day, not-for-profit meeting is entitled 'Implications of the LKB1 and AMPK Systems.
Takeshi Shimamura, PhD Loyola University Chicago BET bromodomain inhibitor resistance in LKB1 deficient mutant KRAS NSCLC Sponsored by Chicago Lung Run
Interestingly, metformin also causes a significant increase in LKB1 protein expression and promoter activity, thereby providing for the first time an additional mechanism by which metformin activates AMPK.
We also show that metformin mediated effect on AMPK is dependent on LKB1(Liver kinase B1) as it failed to activate AMPK-ACC pathway and cell cycle arrest in LKB1 null mouse embryo fibroblasts (mefs).
Obtains License for LKB1 Gene Technology II-24 MolecularMD Develops and Validates Assay Tests to Determine LKB1 Expression and Mutation Status II-25 Abbott's Galectin-3 Assay Awarded CE Marking II-25 Asuragen Introduces BRAF and KRAS Mutation Testing Services II-25 Dako to Acquire IP rights from System Dynamic II-26 Agilent Acquires Dako II-26 Celgene Takes Over Avila Therapeutics II-26 Signal Genetics to Acquire ChipDX II-26 Roche and Med Fusion Form Strategic Alliance II-27 Epistem Inks Supply and Distribution Agreement with Becton Dickinson for Tuberculosis Test II-27 Rosetta Genomics Signs Co-Marketing Agreement with Precision Therapeutics II-28
Phosphorylation of LKB1 at Ser428 by protein kinase C-[zeta] is required for metformin-enhanced activation of AMP-activation protein kinase in endothelial cells.
8,9) These data suggest that LKB1 may play a role in AAH progression to malignancy.
Johns Hopkins University School of Medicine , for "Examining LKB1 Status as a Biomarker for Response of Lung Cancer to Metformin"
The study, " Synergistic antitumor activity of AKT inhibitor MK2206 and FUS1 nanoparticles in LKB1 mutant NSCLC" (Meng J, Lara-Guerra H, Ji L, Roth JA) is authored by a team of investigators from The University of Texas MD Anderson Cancer Center.
New TAK-285 non-clinical data presented at EORTC suggest good target specificity, favorable pharmacokinetics and tumor distribution, efficacy in EGFR- and HER2-expressing xenograft models, activity in tumors harboring activated RAS or inactivated LKB1 mutations and activation of AMPK pathways in cardiac cells.
Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients.