STK11

(redirected from LKB1)

STK11

A gene on chromosome 19p13.3 that encodes a ubiquitously expressed serine/threonine-protein kinase which controls the activity of AMP-activated protein kinase (AMPK) family members, playing a role in various cellular processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. STK11 acts by phosphorylating the T-loop of AMPK family proteins, upregulating their activity.

Molecular pathology
Defects in STK11 are a cause of Peutz-Jeghers syndrome; it has been linked to testicular germ cell tumours and sporadically to non-small cell carcinomas of the lung. Defects in STK11 also promote carcinogenesis, including lung cancer progression and metastasis, and confers in lung adenocarcinoma the ability to trans-differentiate into squamous cell carcinoma.

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References in periodicals archive ?

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth.

Expression of p-AMPK in colorectal cancer revealed substantial diverse survival patterns

Some oncogenes in lung cancers (alteration in TP53, K EGFR, RAS, CDKN2, FHIT, MYC, LKB1 and RB genes) are shown to affect tumor microenvironment to promote immune escape (14).

New Insight of Tumor Microenvironment in Non-Small Cell Lung Cancer

Bu sistemle olusturulan bir diger oldukca favori olan model ise Lkb1:LSLK-RasG12D' dir ve insan metastazina oldukca benzer adenokarsinomlar ve skuamoz hucre karsinomlari gelisir (52).

Experimental Animal Models for Lung Cancer/ Akciger Kanseri Deneysel Modelleri

Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression.

Lung Cancers and the Roles of Natural Compounds as Potential Chemotherapeutic and Chemopreventive Agents

The LKB1 tumor suppressor negatively regulates mTOR signaling.

A Case of Male Primary Pulmonary Choriocarcinoma

The CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss.

EXPRESSION OF NEDD9 IN TRANSBRONCHIAL BIOPSIES OF LUNG ADENOCARCINOMA/EKSPRESIJA NEDD9 U TRANSBRONHALNIM BIOPTATIMA ADENOKARCINOMA PLUCA

The cause of PJS is a mutant gene named STK1, also known as LKB1. This gene is localized at 19p34-p36 and is a serine/threonine kinase that controls growth regulation.

The patients with Peutz-Jeghers syndrome have a high risk of developing cancer

Both these molecules affect similar biological process and it has also been discovered that Sirt1 phosphorylates LKB1, the upstream kinase of AMPK and AMPK activated Sirt1 though Nampt (Cetrullo et al., 2015) AMPK is a serine threonine kinase which acts as a metabolic fuel gauge.

Effect of Butyrate on Genetic Expression of Sirt1/AMPK and Akt/mTOR Axes in Murine Adipose Tissue

Studies have shown that NUCB2/Nesfatin-1 can promote colon cancer cell migration, invasion, and epithelial-mesenchymal transition through LKB1, AMPK/TORC1/ZEB pathways.[17] A study by Yoo et al.

The Level of Nesfatin-1 in a Mouse Gastric Cancer Model and Its Role in Gastric Cancer Comorbid with Depression

AMPK promotes its phosphorylation [24] at the Thr172 residue in its a subunit [25] by using an upstream kinase that was identified as a complex between tumor suppressor protein LKB1 and two accessory subunits STRAD and MO25 [26].

AMPK Activation Mediated by Hinokitiol Inhibits Adipogenic Differentiation of Mesenchymal Stem Cells through Autophagy Flux

AMP competes with ATP for binding to the y regulatory subunit of AMPK [177, 178] and by doing so, greatly increases AMPK activity, but only in the presence of an upstream kinase such as liver kinase B1 (LKB1) [179].

Nutritional Ketosis and Mitohormesis: Potential Implications for Mitochondrial Function and Human Health

Vasquez et al., "Medicine: the kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin," Science, vol.