lissencephaly type 4

(redirected from LIS4)

lissencephaly type 4

A neurodevelopmental disorder (OMIM:614019) characterised by lissencephaly, severe brain atrophy, microcephaly and profound mental retardation.

Molecular pathology
Defects in NDE1, which encodes a protein essential for embryonic development of the cerebral cortex, cause lissencephaly type 4.
References in periodicals archive ?
The 2 remaining subjects in these two instructional groups (LIS2 & LIS4) had Phase 3 risk-coefficient values at least .05 lower than those of Phase 2.