lissencephaly type 3

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lissencephaly type 3

A hereditary brain disorder (OMIM:611603) characterised by a smooth brain surface due to the absence (agyria) or reduction (pachygyria) of the cerebral gyri (surface convolutions); laminar heterotopia, usually associated with psychomotor retardation; severe mental retardation; variable presence of seizures; and defects of the corpus callosum, hippocampus, cerebellar vermis and brainstem.
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References in periodicals archive ?
Animals were fed a commercial diet and randomly assigned to four treatments: control diet (CON group) and diet supplemented with 10 g/kg (LIS1 group) or 20 g/kg (LIS2 group) or 30 g/kg (LIS3 group).
Animals were fed a commercial diet assigned to four dietary treatments: control diet (CON group) and diet supplemented with 10 g/kg (LIS1 group) or 20 g/kg (LIS2 group) or 30 g/kg (LIS3 group).
Supplementing Lisosan G(r) in LIS2 group resulted in a decrease values of TBARS by 41% compared to control group (Pless than 0.01); the LIS1 and LIS3 groups, even presenting lower values than CON group, were not statistically different.
Lisosan G(r) dietary treatment resulted in a significant improvement (Pless than 0.01) of fatty acid profile in experimental LIS1, LIS2 and LIS3 groups, showing a decrease of saturated fatty acids (SFA) and an increase of polyunsaturated fatty acids (PUFAs); even the n-3 and n-6 fatty acids increased (Pless than 0.05) in experimental groups, with a positive and lowering effect on the n-6/n-3 ratio.
Five subjects in the inaccurate rules group (LIS3, HIS1 FIS2, FIS3, & FIS4) and two subjects in the no rules group (HNS5 & FNS5) had Phase 3 risk-coefficient values at least .05 higher than those of Phase 2.