LHX1

(redirected from LIM homeobox protein 1)

LHX1

A gene on chromosome 17q12 that encodes a homeobox transcription factor which plays a key role in the development of the renal and urogenital systems.

Molecular pathology
LHX1 is a candidate gene for Mayer-Rokitansky-Kuster-Hauser syndrome, which is characterised by defects of the female genital tract.
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References in periodicals archive ?
These changes correlated with down-regulation of effectors of differentiation [secreted frizzled-related sequence protein 1 (SJrpl), insulin-like growth factor 1 receptor (Igftr)> wingless-related MMTV-integration site 4 (Wnt4), Lim homeobox protein 1 (Lhxl), E-cadherin].
Next, we monitored the expression of mesenchymal [SfrpI (secreted frizzled-related sequence protein l)]and epithelial [Igfir (insulin-like growth factor 1 receptor), Wnt4 (wingless-related MMTV-integration site 4), Lhxl (Lim homeobox protein 1), and E-cadherin] markers of differentiation by qRT-PCR to determine if morphologic deficits correlated with modulation of genetic targets.