LHX3

(redirected from LIM homeobox 3)

LHX3

A gene on chromosome 9q34.3 that encodes a homeobox protein which binds to and activates the promoter of the alpha-glycoprotein gene, synergistically enhancing transcription from the prolactin promoter in co-operation with Pit-1.

Molecular pathology
Defects in LHX3 cause pituitary hormone deficiency combined type 3.
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References in periodicals archive ?
Transcription factor genes playing a role in the development of hypothalamus and pituitary are pituitary transcription factor 1 (PIT1), Prophet of Pit-1 (PROP1), LIM Homeobox 3 (LHX3), LIM Homeobox 4 (LHX4), and HESX Homeobox 1 (HESX1) which all are known to be important for organ commitment and embryonic pituitary cell differentiation.