S100A9

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S100A9

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which contain 2 EF-hand calcium-binding motifs and as a group regulate cell cycle progression and differentiation and other cellular processes. S100A9 has antimicrobial activity against bacteria and fungi and provides resistance to invasion by pathogenic bacteria, and it upregulates transcription of genes under the control of NF-kappa-B; it is linked to the endotoxic shock response to bacterial lipopolysaccharide. S100A9 promotes tubulin polymerisation and macrophage and granulocyte migration and infiltration into wound sites; it is a pro-inflammatory mediator and upregulates IL8 release and cell surface expression of ICAM1. Extracellular S100A9 (calprotectin) binds to target cells and promotes apoptosis.
 
Molecular pathology
Altered expression of S100A9 is linked to cystic fibrosis.
References in periodicals archive ?
When LIAG is added to the equation, the explanatory power of the model is not increased, nor is the regression coefficient significant (though it has the negative sign that we observed in earlier regressions).
While the independent variables remain the same, namely: FLIAG, FIAG, LIAG, WIAG, TWIAG, and CIAG, the dependent variables are now in terms of the small farms' relative shares.
But an LIAG spokesman said: "Having a landfill site in such close proximity to residential areas - with the prevailing wind blowing off the proposed sites -will pose a serious health threats to neighbouring communities.
BEER'S TO YOU J Toast in the Slieve Liag pub for Lotto winner
There are already five existing landfill sites within a 3 km circle and another two would mean the community would be encircled by what LIAG has dubbed a super tip.
In a statement LIAG said: "The area of Buckley, Alltami, Ewloe Green, Ewloe & Drury has had an active landfill site within the above communities for the past 30 years.
Flintshire's Local Issues Action Group (LIAG) says that despite consultation over North Wales' regional waste plan beginning in October, many were not aware of their right to have a say until December 3.
A LIAG spokesman said: "We are very concerned at the lack of consultation with the wider population of Flintshire.
Buckley county councillor Carol Ellis, also a member of Local Issues Action Group (LIAG), said: "This adds more weight to the argument that the application should be heard at a public inquiry."
Tenders are invited for The Project Will Involve Works Along Various Sections Of The Cliff Top Path, Sliabh Liag Mountain, To Enhance The Visitor Experience And To Protect Against Further Erosion Of The Mountain.
Tenders are invited for Sliabh liag strategic development project - car park & rangers station