S100A9

(redirected from LIAG)
Also found in: Acronyms.

S100A9

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which contain 2 EF-hand calcium-binding motifs and as a group regulate cell cycle progression and differentiation and other cellular processes. S100A9 has antimicrobial activity against bacteria and fungi and provides resistance to invasion by pathogenic bacteria, and it upregulates transcription of genes under the control of NF-kappa-B; it is linked to the endotoxic shock response to bacterial lipopolysaccharide. S100A9 promotes tubulin polymerisation and macrophage and granulocyte migration and infiltration into wound sites; it is a pro-inflammatory mediator and upregulates IL8 release and cell surface expression of ICAM1. Extracellular S100A9 (calprotectin) binds to target cells and promotes apoptosis.
 
Molecular pathology
Altered expression of S100A9 is linked to cystic fibrosis.
References in periodicals archive ?
While the independent variables remain the same, namely: FLIAG, FIAG, LIAG, WIAG, TWIAG, and CIAG, the dependent variables are now in terms of the small farms' relative shares.
There are already five existing landfill sites within a 3 km circle and another two would mean the community would be encircled by what LIAG has dubbed a super tip.
A LIAG spokesman said: "We are very concerned at the lack of consultation with the wider population of Flintshire.