LHX1

LHX1

A gene on chromosome 17q12 that encodes a homeobox transcription factor which plays a key role in the development of the renal and urogenital systems.

Molecular pathology
LHX1 is a candidate gene for Mayer-Rokitansky-Kuster-Hauser syndrome, which is characterised by defects of the female genital tract.
References in periodicals archive ?
The investigators were able to differentiate both human ES cells and human iPS cells into cells expressing PAX2 and LHX1, two key markers of the intermediate mesoderm.
Other genes identified in precursor lesions include PENK, CDKN2A/p16, STK11/LKB1, SPARC, SFRP1/SARP2 (chromosome arm 8p), TSLC1, RELN (chromosome arm 7q), TFPI2, CLDN5 (chromosome arm 22q), and UCHL1 in IPMNs (37,122,123); PENK, CDKN2A/p16, CLDN5, NPTX2, RPRM, SFRP1/SARP2, and LHX1 (chromosome arm 11p) in PanINs (117,118,124); and CDKN2A/p16 in MCNs.