gonadotropin-releasing hormone analogue

(redirected from LHRH analogue)

gonadotropin-releasing hormone analogue

A polypeptide analogue of gonadotropin-releasing hormone–GnRH; some are more potent than GnRH in stimulating gonadotropin release Examples Leuprolide, histrelin, administered in a pulsatile fashion to restore lost GnRH, normalize pituitary-gonadal function, as in congenital GnRH deficiencies–eg, hypogonadotropic hypogonadism with Kallmann syndrome or without anosmia, or in acquired GnRH deficiency secondary to RT of the CNS, pituitary tumors, or panhypopituitarism. See Gonadotropin-releasing hormone.
References in periodicals archive ?
In contrast to the NCIC-PR7 trial, which allowed treatment with orchiectomy or any LHRH analogue, the ICELAND study only allowed treatment with leuprolide acetate, which may account for the disparity in results.
Effect of treatment with LHRH analogue on oocyte maturation, plasma sex steroid levels and eggs production in female striped trumpeter Latris lineata (Latreidae).
Effectiveness of an LHRH analogue for the induced spawning of carp catfish in Northeast Thailand.
Premenopausal women undergoing treatment with an LHRH analogue were randomised to either tamoxifen or anastrozole, with or without zoledronic acid, to assess long-term bone safety in the ABCSG-12 trial [10,11] (Figure 2).
(2) Patients with localized high-risk prostate cancer (clinical stage T1c/T2 and Gleason score 8 or higher, or stage T2b or higher and Gleason score 7 or higher and prostate-specific antigen [PSA] higher than 10 ng/mL) were randomly assigned in a 2:1 ratio to 24 weeks of treatment with either abiraterone plus enzalutamide plus LHRH analogue or abiraterone acetate plus LHRH analogue.
Despite nearly undetectable PSA levels in both groups of patients, there was a trend toward more tumour down-staging to pathology stage ypT2N0 or lower in the group that received abiraterone acetate plus LHRH analogue than in the group that received enzalutamide plus abiraterone acetate plus LHRH analogue.
Long-term administration of an LHRH analogue will eventually lead to down regulation of LHRH receptors, thus suppressing FSH and LH secretion.
LHRH analogues arc used in patients who cannot tolerate tamoxifen.
In the trial, CB7630 was administered once daily to chemotherapy-naive patients with castration refractory prostate cancer (CRPC), who had progressive disease despite treatment with LHRH analogues and multiple other hormonal therapies including antiandrogens, diethylstilboestrol and dexamethasone.
We also assessed whether there is a difference in testosterone levels between patients who use different LHRH analogues.