To better demonstrate the presence of targeting LHRH
peptide in the conjugate, UV spectra were also recorded for LHRH
-PEG-PHIS, and PHIS (Fig.
12] These authors studies 73 patients with non-metastatic prostate cancer receiving 3-month depots of LHRH
In absence of LHRH
, this inhibition was significant from 10 [micro]g/ml for A.
We tallied the T levels of the total 69 patients (Table 2); we further detailed the T levels based on the type of LHRH
agonist, excluding MAB (Table 3).
In response to the LHRH
signal, the pituitary gland produces two protein hormones called gonadotropins.
EP-100 is a targeted membrane-disrupting peptide coupled to LHRH
and is designed to bind selectively to LHRH
receptors which are overexpressed in a wide range of cancers.
The percentage of treatment compliant subjects receiving 1500 mg of GTx-758 who achieved medical castration was comparable to rates of castration observed with LHRH
This Phase I study with zoptarelin doxorubicin which targets these LHRH
receptors, determined the maximum tolerated dose ("MTD") of this agent in men with taxane- and castration-resistant PC while providing additional information on its safety profile and efficacy.
Acting on pituitary LHRH
receptors, they initially stimulate a transient rise in serum follicle-stimulating hormone (FSH) and LH.
In the second quarter of 2011, GTx is planning to initiate a Phase IIb clinical trial evaluating Capesaris head to head compared to LHRH
agonist treatment in men with advanced prostate cancer.
Regardless, the actual testosterone level is important for patients on LHRH
agonists with rising PSA.
In addition, GTx plans to advance Capesaris into a Phase II study for second line therapy for patients with castration resistant prostate cancer who have failed LHRH