Treatment is now not recommended as an option in women with CIN 1 who have previously had ASC-US, ASC-H, or LGSIL.
When it comes to considering alternative treatments, we can consider our topical and systemic options for helping to clear the virus and the abnormal cells changes, especially for ASC-US and LGSIL.
A recent study conducted by the College of American Pathologists defined the limits of the Pap smear(25): if a positive smear is defined as LGSIL or worse, the false-negative rate is 5%.
A recent study showed that only 50% of cases interpreted as LGSIL by cytologic examination could be confirmed on biopsy, and 11% were actually HGSIL.
LGSIL, which denotes low-grade squamous intraepithelial lesion, equates to cellular changes associated with mild dysplasia, cervical intraepithelial neoplasia I (CIN 1) or human papillomapirus (HPV); HGSIL, high-grade squamous intraepitbclial Icsion, equates to moderate dysplasia (CIN2) or severe dysplasia (CIN 3 or carcinoma in situ).
See and Treat" Colposcopic Impression ELECTZ Histology LGSIL, n HGSIL, n Other, n Negative(*) 13 2 1 LGSIL 7 1 2 HGSIL 4 16 0 Total 24 19 3
21) Consideration should be given to treating LGSIL
that persists for over 1 year.