RXFP2

(redirected from LGR8)

RXFP2

A gene on chromosome 19p13.3 that encodes a transmembrane G protein-coupled receptor. RXFP2 is a receptor for relaxin and possibly also for insulin-like 3 (Leydig cell) factor.
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References in periodicals archive ?
LGR8 has been identified as the INSL3/relaxin receptor and was shown in vitro to promote a strong proliferative response in fetal rat gubernaculum cells upon exposure to rat INSL3.
Zhang et al., "Defining the LGR8 residues involved in binding insulin-like peptide 3," Molecular Endocrinology, vol.
Elle debute entre la 8[sup.e] et la 15[sup.e] semaine de gestation par le transit intra-abdominal, controle principalement par l'hormone insulin-like 3 (INSL3) et son recepteur couple a la proteine-G riche en motifs leucine repetee 8 (LGR8), et se poursuit au cours du 7[sup.e] mois de gestation par la migration inguinoscrotale sous influence hormonale androgenique[sup.1].
28 Yan Y, Cai J, Fu P, Layfield S, Ferraro T, Kumagai J, et al.Studies on soluble ectodomain proteins of relaxin (LGR7) and insulin 3 (LGR8) receptors.