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Biotechnology company PolarityTE Inc (Nasdaq:PTE) reported on Tuesday the receipt of a Canadian patent entitled "Methods for Development and Use of Minimally Polarized Function Cell Micro-Aggregate Units in Tissue Applications Using LGR4, LGR5 And LGR6 Expressing Epithelial Stem Cells."
MCLA-158 (Lgr5 x EGFR Biclonics): Emerging data from Phase 1 trial expected at end of 2019
2 969 707 entitled "Methods for Development and Use of Minimally Polarized Function Cell Micro-Aggregate Units in Tissue Applications Using LGR4, LGR5, And LGR6 Expressing Epithelial Stem Cells." This patent relates to PolarityTE's unique micro-aggregate technology capable of assembling functional polarized tissue, as well as methods for producing compositions including these micro-aggregates, and the use of these micro-aggregates for therapeutic treatment of skin, skin repair and skin restoration.
Gastric Lgr5 (+) stem cells are the cellular origin of invasive intestinal-type gastric cancer in mice.
(5) The study looked at tissue biomarkers Lgr5, CD133, and CD44, to use for stage assessment and help clinicians set follow up care timeframes.
B) Analysis of stem cell proliferation marker gene LGR5 expression by quantitative reverse transcription PCR in undifferentiated HIEs.
The lower crypt compartment consists of pluripotent stem cells residing at the bottom of the crypt, recently identified by the stem cell marker Lgr5 and proliferating transit amplifying cells that differentiate into mature cell lineages (Absorptive, goblet and enteroendocrine cells) during migration toward the villus compartment.
Kuipers et al., "Identification of stem cells in small intestine and colon by marker gene Lgr5," Nature, vol.
Intestinal stem cell marker LGR5 is known to be upregulated in human colon cancers and sporadic adenomas .
Studies on murine hair follicles have also revealed expression of, inter alia, CK19 [8, 22] and numerous transcription factors, that is, Sox9, Lgr5, Gli1, Hopx, LHX2, Nfatc1, and Tcf3 [8, 25].
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.
Barriga et al., Mex3a marks a slowly dividing subpopulation of Lgr5 intestinal stem cells," Cell Stem Cell, March 2017 DOI:10.1016/j.stem.2017.02.007
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