LGALS2

(1) A gene on chromosome 22q13.1 that encodes a galectin family-type carbohydrate-binding protein, which is implicated in modulating cell-cell and cell-matrix interactions, and may regulate apoptosis, cell proliferation and cell differentiation.
(2) This is also a retired HUGO symbol for what is now designated LGALS3, see there.

References in periodicals archive ?

Interestingly, in a search for genes associated with insulin resistance, a genotype of galectin-2, LGALS2 rs7291467, was stronger associated with changed fasting plasma glucose and serum insulin than other alleles were [26], and the same genotype which has a single-nucleotide polymorphism (3279C [right arrow] T) in intron 1 of LGALS2 encoding galectin-2 was previously found to be significantly associated with myocardial infarction [27].

Gaunt et al., "Genotype of galectin 2 (LGALS2) is associated with insulin-glucose profile in the British Women's Heart and Health Study," Diabetologia, vol.

The Role of Galectins as Modulators of Metabolism and Inflammation

Huang, "PPARG, AGTR1, CXCL16 and LGALS2 polymorphisms are correlated with the risk for coronary heart disease," International Journal of Clinical and Experimental Pathology, vol.

The Impact of tagSNPs in CXCL16 Gene on the Risk of Myocardial Infarction in a Chinese Han Population

Whereas a study in the Japanese population showed a functional single-nucleotide polymorphism (SNP) rs7291467 (C3279C[left arrow]T) in the Gal-2 gene (LGALS2) that was associated with increased risk of AMI [92], these results could not be confirmed in Caucasian individuals, and a meta-analysis of seven studies showed no association between LGALS2-C3279T and coronary artery disease [93].

Galectin-1 as an Emerging Mediator of Cardiovascular Inflammation: Mechanisms and Therapeutic Opportunities

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