Interestingly, in a search for genes associated with insulin resistance, a genotype of galectin-2, LGALS2 rs7291467, was stronger associated with changed fasting plasma glucose and serum insulin than other alleles were , and the same genotype which has a single-nucleotide polymorphism (3279C [right arrow] T) in intron 1 of LGALS2 encoding galectin-2 was previously found to be significantly associated with myocardial infarction .
Gaunt et al., "Genotype of galectin 2 (LGALS2) is associated with insulin-glucose profile in the British Women's Heart and Health Study," Diabetologia, vol.
Huang, "PPARG, AGTR1, CXCL16 and LGALS2
polymorphisms are correlated with the risk for coronary heart disease," International Journal of Clinical and Experimental Pathology, vol.
Whereas a study in the Japanese population showed a functional single-nucleotide polymorphism (SNP) rs7291467 (C3279C[left arrow]T) in the Gal-2 gene (LGALS2
) that was associated with increased risk of AMI , these results could not be confirmed in Caucasian individuals, and a meta-analysis of seven studies showed no association between LGALS2-C3279T and coronary artery disease .