IFITM1

(redirected from LEU13)

IFITM1

A gene on chromosome 11p15.5 that encodes an interferon-induced protein, which mediates innate cellular immunity against viral pathogens—e.g., influenza A H1N1, West Nile, and dengue viruses—by inhibiting the early steps of viral replication. IFITM1 downregulates IFN-gamma by inhibiting ERK activation, or by arresting p53-dependent cell growth in G1.
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References in periodicals archive ?
Amino acid residues, that is, Arg117, His118, Val120, Arg121 and Arg3, Leu13, Gly1, Thr2, Leu123 and Leu16, Ser4 and Ser5, Pro119, Cys6, and Leu7 of TLP were found to involve in binding with membrane ergosterol through van der Waals interactions; however, Gln 139 amino residue interacts with the ergosterol through hydrogen bonding pattern as shown in Figure 7.