CXCR4

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CXCR4

A gene on chromosome 2q21 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which binds specifically to stromal cell-derived factor-1, transducing a signal by increasing intracellular calcium ions and enhancing MAPK1/MAPK3 activation. It acts as a receptor for extracellular ubiquitin, is involved in haematopoiesis and in cardiac ventricular septum formation, plays a role in gastrointestinal tract vascularisation by regulating vascular branching and/or remodelling in endothelial cells, may be involved in cerebellar development and, in the CNS, may mediate hippocampal-neuron survival.

Molecular pathology
CXCR4 acts with the CD4 to support HIV entry into cells; it is highly expressed in breast cancer cells. CXCR4 mutations cause WHIM (warts, hypogammaglobulinaemia, infections, and myelokathexis) syndrome.
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MENTRWCH draw i'r Ffatri Bop yng Nghwm Rhondda ar gyfer rhaglen sy'n cynnig mwy o ddychymyg, mwy o agwedd, a mwy o eitemau cerddorol nag unrhyw lestr adloniadol arall.
Dyn disglair a guddiodd ei gannwyll dan lestr er mwyn goleuo bywyd ei ardal.