LEP


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LEP

A gene on chromosome 7q31.3 that encodes leptin, a protein secreted by white adipocytes, which plays a key role in regulating body weight. By binding to its cognate receptor, leptin is part of a signalling pathway which inhibits food intake and regulates energy expenditure to maintain fat homeostasis. Leptin plays a role in the endocrine system, and is involved in regulating immune and inflammatory responses, haematopoiesis, angiogenesis, reproduction, glucose homeostasis, bone formation, and wound healing.

Molecular pathology
Mutations of LEP and/or its regulatory regions are linked to obesity, morbid obesity with hypogonadism, and type-2 diabetes.
References in periodicals archive ?
Review "Following a national review, government has issued a directive that all LEPs must have a legal personality."
Christine Gaskell CBE joined business leaders representing each of the LEPs across England to brief the Prime Minister on the development of their Local Industrial Strategies, which will see LEPs work closely with government to unlock growth.
And they said the Government appeared to have no mechanism in place for dealing with LEPs that fail.
Believed to be the first appointment of its kind among UK LEPs, PR consultant Sophie Drake has joined the board for a three-year tenure as a non-executive director.
Mr Hough said that whoever succeeds him will find the LEP in good shape and that the city region has huge opportunities ahead of it for economic growth.
Simon Henig, chairman of the combined authority and leader of Durham County Council, said: "The local government representatives on the LEP were unable to attend the last board meeting.
"Business led LEPs will continue to have a critical role in shaping and implementing devolution deals.
"That becomes even more significant as Government hands over hundreds of millions of pounds to the LEP. I think it is really important that we look at the way that the LEP operates."
Other combined authorities, such as Greater Manchester, the North East and the Liverpool City Region authorities, have a single LEP with the same boundaries.
In terms of LEP performance, it was found that students who learnt science and mathematics in Tamil achieve the highest score of 11.37 (0.63), followed by those who learnt science and mathematics in English as a medium of TnL with a score of 10.91 (0.57) and those who learnt science and mathematics in Chinese as a medium of TnL with a score of 10.72 (0.18).
"Centre for Cities fails to appreciate the local characteristics of the Tees Valley LEP and the unique solutions it is delivering.
Aside from the energy savings, LEP has a number of other important attributes, ranging from dimmability, to expected lifetime, to color.