SPINK5

(redirected from LEKTI)

SPINK5

A gene on chromosome 5q32 that encodes a multidomain serine protease inhibitor with 15 potential inhibitory domains, which may play a role in skin and hair morphogenesis and anti-inflammatory and/or antimicrobial protection of mucous epithelia.

Molecular pathology
SPINK5 mutations cause Netherton syndrome.
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Netherton syndrome is caused by homozygous or compound heterozygous mutations in the SPINK5 gene, which encodes the serine protease inhibitor LEKTI (lymphoepithelial Kazal-type-related inhibitor), on chromosome 5q32 (2).
Immunohistochemistry using specific antibodies showed complete absence of lymphoepithelial Kazal-type-related inhibitor (LEKTI) in the biopsy specimen.
The gene encodes a serine protein kinase known as lymphoepithelial Kazal-type inhibitor (LEKTI), expressed in mucosal and epithelial surface [2-4].
The proteolytic activity is dependent on pH in the SC and is regulated by a cocktail of protease inhibitors, including lymphoepithelial Kazal-type 5 serine protease inhibitor (LEKTI) encoded by the serine protease inhibitor Kazal-type 5 (SPINK5) [48].
Lopez et al., "LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction," Molecular Biology of the Cell, vol.
FLG, its major processing proteases and key protease inhibitor lymphoepithelial Kazal-type-related inhibitor (LEKTI) were measured by both real-time quantitative polymerase chain reaction and Western blotting.
FLG has several site-specific functions governed by the program of epidermal terminal differentiation in which a number of proteases are involved, such as corneum trypsin- and chymotrypsin-like enzymes (stratum corneum tryptic enzyme/kallikrein 5 [KLK5] and stratum corneum chymotryptic enzyme/KLK7),[sup][9],[10],[11] channel-activating serine protease1 (CAP1),[sup][12] matriptase (coded by ST14),[sup][12] and cysteine protease caspase-14[sup][13] and their key protease inhibitor lymphoepithelial Kazal-type-related inhibitor (LEKTI) (encoded by serine protease inhibitor Kazal-type 5 gene/ SPINK5 ).[sup][12],[13],[14] All of the proteases can enhance FLG degradation processing.
Janulyte's work for solo flute Kas yra istyres Liepos nakties bedugne, kiek sieksniu reikia lekti gilyn i tustuma, kurioje nieko nebeivyksta?
In Netherton syndrome, mutations occur in SPINK5, a serine protease inhibitor that encodes a critical serine protease inhibitor, lymphoepithelial-Kazal-type 5 inhibitor (LEKTI).
In Netherton syndrome, mutations occur in 5PINK5, a serine protease inhibitor that encodes a critical serine protease inhibitor, lymphoepithelial-Kazal-type 5 inhibitor (LEKTI).
However, other studies, using appropriate controls, have found no relation between diversity and trust, either at the cross-national level (Green, Preston and Janmaat, 2006; Hooghe et al., 2009) or in cross-area analyses in Canada (Johnson and Soroka, 1999) and the UK (Lekti, 2006).