LEFTY2

LEFTY2

A gene on chromosome 1q42.1 that encodes a member of the transforming growth factor beta (TGFB) family of cytokines that plays a role in determining left-right asymmetry during organogenesis and may also play a role in endometrial bleeding.
 
Molecular pathology
LEFTY2  mutations are associated with left-right axis malformations, especially in the heart and lungs; some types of infertility are associated with dysregulated LEFTY2 expression in the endometrium.
References in periodicals archive ?
All three factors together upregulate teratocarcinoma-derived growth factor 1 (TDGF1), left-right determination factor 2 (LEFTY2), dickkopf-related protein 1 (DKK1), and GSK-3-binding protein.
Moreover, maternal smoking has been shown to alter the expression of genes related to neuropeptide signaling and signal transduction, as well as development, particularly tachykinin 3 (TAC3), left-right determination factor 2 (LEFTY2), heparin-binding EGF-like growth factor (HBEGF), mitochondrial fission factor (MFF), and fibulin1 (FBLN1), via mechanisms possibly related to genome-wide changes in DNA methylation [159].
miR-302 inhibits differentiation by inhibiting the differentiation factors Lefty1 and Lefty2 to maintain embryonic stem cell proliferation [37].