LEFTY1

LEFTY1

A gene on chromosome 1q42.1 that encodes a member of the transforming growth factor beta (TGFB) family of cytokines that plays a role in determining left-right asymmetry during organogenesis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Chevassut, "Nanog Requires BRD4 to Maintain Murine Embryonic Stem Cell Pluripotency and Is Suppressed by Bromodomain Inhibitor JQ1 Together with Lefty1," Stem Cells and Development, vol.
miR-302 inhibits differentiation by inhibiting the differentiation factors Lefty1 and Lefty2 to maintain embryonic stem cell proliferation [37].
pathway Integrated pancreatic MAPK8, CDKN2B, LTBP1, LEFTY1, RAF1, et al.
Antagonistic regulation of left right determination factor 1 (LEFTY1) by Dex and [E.sub.2] in Ishikawa cells was previously shown to be mediated by GR and ER (Whirledge et al.
Analysis of gene expression in the presence of GR and ER inhibitors indicates that these receptors are required for the antagonistic regulation of CA12, LEFTY1, and GILZ by Dex and Gen.
The in vivo significance of glucocorticoid regulation of LEFTYI and GILZ in the uterus is not clear, but both LEFTY1 and GILZ regulate important biological functions.