LE cell


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LE cell

 
a neutrophil or macrophage that has ingested the nuclear material of an injured cell, converted to a dense, homogeneous mass by reaction with antinuclear antibodies; this mass of nuclear material is called a hematoxylin body. This is a characteristic of systemic lupus erythematosus, but also found in analogous connective tissue disorders.

LE cell

a polymorphonuclear leukocyte containing an amorphous round body that is a phagocytosed nucleus from another cell plus serum antinuclear globulin (IgG) and complement; formed in vitro in the blood of patients with systemic lupus erythematosus.

LE cell

(sel)
A polymorphonuclear leukocyte containing an amorphous round body; formed in vitro in the blood of patients with systemic lupus erythematosus, or by the action of the patient's serum on normal leukocytes.
Synonym(s): lupus erythematosus cell.
References in periodicals archive ?
To confirm if the gene products are associated with transition of the endometrium to refractory in vivo, recombinant FGF2 and FGF9 proteins (rFGF2 and rFGF9, respectively) were administered to DI mice and LE cell proliferation was analyzed after administration.
When E2 or LIF was administered to DI mice, high-dose E2 (20 ng) stimulated LE cell proliferation after 24 hr (Figure 1M).
Table 1 Comparison of Immune Complex Formation in the Autoimmune Diseases Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) Immune response RA SLE Diagnostic RA cell (phagocytes LE cell (phagocytes tell-tale cell with ingested with ingested cell rheumatoid factor nuclei) complexes) Antigen Hinge region of IgG DNA, histones, etc.
LE cells are neutrophilic phagocytes that contain intracytoplasmic hematoxylin bodies.