LMNA

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LMNA

A gene on chromosome 1q22 that encodes lamin A/C, a protein highly conserved in evolution that forms part of the two-dimensional matrix of proteins located next to the inner nuclear membrane. Lamins are involved in providing nuclear stability and chromatin structure, and in gene expression.

Molecular pathology
LMNA mutations cause the so-called laminopathies—e.g., Charcot-Marie-Tooth disease type 2B1, progeria (Hutchinson-Gilford syndrome), dilated cardiomyopathy, Emery-Dreifuss muscular dystrophy type 2, familial partial lipodystrophy, limb-girdle muscular dystrophy type 1B, mandibuloacral dysplasia, and some cases of Werner syndrome.
References in periodicals archive ?
Out of them, there were two couples of hybrid genotypes originated from the same parents, of which one couple is PH8 and PH9 and the other one is LDP1 and LDP2.
1A), VN1, VN3 and Keoamtich were presented in one small sub-group forming a group of small- leaved China type, and the remaining small sub-group was nested by the crosses LDP1 and LDP2 (Assam-small leaved China type, and also known as offspring of the same parents), and PH10 (small leaved China type).
Among them, only Keoamtich was appeared alone, while the same parental crosses LDP1 and LDP2 were presented in one sub-group, and the single cluster consisted of DS13 and DS15 together with VN1 were presented in the other sub-group.
The report added: "Since LDP1 was withdrawn in March, work on preparing LDP2 has commenced.
33 N 3,308 1,431 631 253 Descriptive Statistics (Median) LDP1 JSP LDP2 DPJ Last margin 0.
New clonal types, such as LDP1, LDP2, PH1 and #777 are slowly being introduced by the Northern Mountainous Agriculture and Forestry Science Institute (formerly, Phu Ho Tea Research Institute) for higher yields, higher quality or improved adaptation to poor soil quality.
NEW YORK -- Fitch Ratings takes various rating actions on JP Morgan 2005 LDP1, commercial mortgage pass-through certificates.