LDLR


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LDLR

A gene on chromosome 19p13.2 that encodes a cell surface protein involved in receptor-mediated endocytosis of low-density lipoprotein (LDL), the major cholesterol-carrying lipoprotein of plasma, which it transports into cells by endocytosis. Internalisation of the receptor-ligand complex requires clustering into clathrin-coated pits.
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Caption: Figure 4: Effects of quercetin on (a) GSK-3[beta], (b) GCK, (c) SREBP- 1c, and (d) LDLR expression.
Caption: Figure 4: Effect of LDL receptor (LDLR) blocking with antibody on the nLDL-induction of senescence in HUVECs.
Classical are cases with tendon xanthomas in patients along LDLR gene mutation with hyperlipidemia.
Asi, los marcadores geneticos "convencionales" (HLA-DQA1, LDLR, GYPA, HBGG, D7S8, Gc, D1S80) fueron utiles para atender una importante cantidad de casos en cede judicial (n>300).
It was also observed from FCM data that the fluorescence intensity of LDL/SLN/DTX/TDD was approximately 2.07-fold higher than that of SLN/DTX/ TDD after incubation for 6 h, suggesting that LDL/SLN/ DTX/TDD can be more effectively internalized by HepG2 cells than its counterpart SLN/DTX/TDD, possibly via the LDLR mediated endocytosis pathway.
[beta]-VLDL accumulate in the plasma because apoE2 is defective in LDLR binding (approximately 2% of normal).
Future studies using LDLr -/- mouse models may be necessary to establish possible linkages to the pathogenesis of atherosclerosis [12,13].
Conclusions: The following mechanisms may have mediated the decrease in plasma lipids levels in mice: a down-regulation of hepatocyte-cholesterol synthesis occurred as a result of decreased HMGCR protein levels and catalytic activity; the levels of LDLR mRNA became elevated, thus suggesting an increase in the uptake of serum LDL, especially by the liver; and TG synthesis became reduced very likely because of a decrease in fatty-acid synthesis.
An inherited genetic disorder that can be confirmed by detecting the LDLR gene is
Berberine also can acts via stabilization of hepatic LDLc receptor (LDLR) and increasing transcriptional activity of LDLR promoter and down regulation of many transcription factors related to lipogenesis prCesses (Kong et al., adipogenic enzymes and transcription factors (Choi et al., 2006).
(1,2) The etiology of FH comprises of known mutations in the gene of the LDL receptor (LDLR) (with more than 1600 identified to date, (3) the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene, the gene of apolipoprotein B (ApoB) or rare mutations in LDL receptor adapter protein 1 (LDLRAP1) gene.
The curcumin acting on the low density lipoprotein receptor (LDLR) expression which is measured by Fluo-Microscopy and Fluorescence Flow Cytometric Methods in HepG2 cell obviously upregulated the expression of LDLR [75].