LDL-C


Also found in: Acronyms.

LDL-C

 
low-density-lipoprotein cholesterol; see cholesterol.

LDL-C

low-density-lipoprotein cholesterol

LDL-C

Abbreviation for low density lipoprotein-cholesterol.
References in periodicals archive ?
Initial results from the trial showed that evolocumab lowered LDL-C levels to a median of 0.
With a targeted mechanism of action, bempedoic acid is a first-in-class ACL inhibitor that reduces cholesterol biosynthesis and lowers elevated levels of LDL-C by up-regulating the LDL receptor, but with reduced potential for muscle-related side effects, according to the company.
Results: Mean difference of measured and calculated LDL-C was found to be -0.
In a further analysis that included 54,884 individuals who were at least 50% adherent to their statin therapy, there was a slightly increased risk of major cardiac events in patients who achieved a low LDL-C, compared with those in the moderate LDL-C group, and a significant 13% reduction in risk in the moderate LDL-C group, compared with the high LDL-C group.
Several classic outcomes studies have established CV risk reduction by LDL-C reduction using statins.
Weight loss has been associated with reductions in LDL-C.
Although we did not try to answer the question in our original article, it is possible that the difference (44 mg/dL) between the calculated low-density lipoprotein cholesterol (LDL-C; 172 mg/dL) and the directly measured LDL-C (128 mg/dL) lies in (1) the use of triglycerides (TG) divided by 5 in the Friedewald formula and (2) the cholesterol of other lipoprotein fractions, such as intermediate-density lipoprotein cholesterol (IDL-C), Lp(a) (lipoprotein(a)), apo E-rich high-density lipoprotein cholesterol, etc, that may not be measured, partially or fully, by the homogeneous LDL-C assay.
Participants were then divided into 4 groups: the reference group, a group with an LDL-C genetic score below the median (resulting in lower LDL-C), a group with a SBP genetic score below the median (resulting in lower SBP), and a group with both LDL-C and SBP genetic scores below the median (resulting in both lower LDL-C and lower SBP).
To assess the relationship between LDL-C and HDL-C with CV risk in RA patients compared with the general population, the researchers compared 16,085 RA patients with 48,499 matched controls without RA from the United Healthcare database.
From the outset, the NCEP recognized the importance of accurate and reproducible assessment for LDL-C and convened an expert panel of laboratory scientists to address the standardization of the lipid measurements included in the guidelines (8, 9).
Across the four different dosing regimens tested, patients who received SAR236553/REGN727 for 12 weeks achieved a mean LDL-C reduction from baseline of 28.
The National Cholesterol Education Program Adult Treatment Panel III Report (NCEP-ATP III) has identified low-density lipoprotein cholesterol (LDL-C) as the primary target of therapy and has recommended using the Friedewald calculated LDL-C (C-LDL-C).