LDL

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LDL

 
low-density lipoprotein.

LDL

Abbreviation for low density lipoprotein. see under lipoprotein.

LDL

low-density lipoprotein.

LDL

(ĕl′dē′ĕl′)
n.
A lipoprotein with a relatively high concentration of lipids and low concentration of protein that incorporates cholesterol and transports it to cells. High levels are associated with an increased risk of atherosclerosis and coronary artery disease. Also called LDL cholesterol.

LDL

abbreviation for low-density lipoprotein.

LDL

Low-density lipoprotein Beta-lipoprotein A 3000 kD plasma lipoprotein–
normal serum concentration 60-155 mg/dL–which has a central role in transporting cholesterol from the intestine to the liver ↑ in Nephrotic syndrome, obstructive jaundice, uncontrolled DM, type II hypercholesterolemia; ↓ in Familial LDL deficiency. See Cholesterol, Small LDL. Cf HDL.

LDL

Abbreviation for malondialdehyde-modified low-density lipoprotein.

LDL

Abbrev. for low density LIPOPROTEINS.

Low density lipoproteins (LDL)

A blood-plasma lipoprotein that is high in cholesterol and low in protein content and that carries cholesterol to cells and tissue; also called bad cholesterol.

LDL

low-density lipoproteins

low-density lipoprotein

; LDL cholesterol-transporting plasma lipid particles; normal values = 1.5-4.4 mmol/L; raised blood LDL cholesterol is a noted risk factor of atheroma and peripheral vascular disease

LDL,

LDL

low-density lipoprotein.

LDL receptors
specialized receptor proteins for binding low-density lipoproteins; clustered on the plasma membrrane in a structure called a coated pit, an invagination containing the protein clathrin. On binding with LDL, the plasma membrane fuses near the receptor-LDL complex and the coated pit becomes an endocytotic vesicle which is transported into the cell, fuses with the lysosomes enabling contact between the LDL-receptor complex and hydrolytic enzymes of the lysosomes.

Patient discussion about LDL

Q. How can I increase my HDL cholesterol levels? My Doctor told me that my cholesterol levels are not good and that I should lower my LDL and higher my HDL. I understand how to lower the cholesterol, but how can I increase the HDL?

A. a good way is to eat boiled fish, and instead of regular oil, add olive oil to your salad.

Q. Improving High Triglycerides I take Tricor for high triglyceride levels; I have a healthy level of total cholesterol, with low LDL, very good HDL. I am now being treated for hypothyroidism, but my doctor says that it's also genetic (I had almost the exact same level number as my brother). How can I work to get my triglycerides under control?

A. High level of triglycerides are generally both genetic and diet related. If you are consuming a high fat containing diet then your level of triglycerides will be increased. On the other hand, regardless of your good cholesterol levels, if you start lowering the amount of fat in your food (less oil, less sweets, less red meat) and combine it with physical activity you can lower your triglycerides level, especially if you are already on medications.

Q. Does wight loss lowers cholesterol? I'm 5'5, 175 lbs, 40 years-old man. After my doctor found that I have high LDL cholesterol, I was advised to try to lower my weight in order to reduce my cholesterol levels. Otherwise I'll have to start taking medications. Can it really do something? As far as I know, cholesterol level are pretty much a genetic thing, and one can be very thin but still have high cholesterol levels.

A. One of the best things you should do is to take a good multivitamin multimineral supplement. And of course, changing your lifestyle. Supplementing your diet with vitamins can help you reduce your LDL cholesterol levels and increase HDL. Also, increase your intake of omega 3 fatty acids, but make sure that you know the source they are from before taking them.

More discussions about LDL
References in periodicals archive ?
Effects of tincture of crataegus on the LDL receptor activity of hepatic plasma memb- rane of rats fed on atherogenic diet atherosclerosis.
Common variation of the intact LDL receptor allele may also exert subtle influence on serum cholesterol levels in patients with heterozygous FH.
The genes whose mutations cause the heterozygous FH phenotype are the LDL receptor, [apoB.
At the same time, expression of the gene, which produces LDL receptors that help to clear plasma cholesterol was increased by 60%.
One in 500 people have familial hypercholesterolaemia which means they have few LDL receptors that remove cholesterol.
Additionally, a large apoB-100 molecule is located at one pole of the LDL and acts as a recognition site for LDL receptors on almost all cells of the body (Pentikainen et al.
The research pair have since discovered that a family of proteins called sterol regulatory element binding proteins (SREBPs) controls the LDL receptors and regulates cholesterol levels in the body--a finding that forms the basis for using statin drug therapy to lower cholesterol levels.
The dense LDLs are more susceptible to oxidation, have a reduced affinity for LDL receptors, and are more likely to penetrate vascular walls, leading to greater endothelial dysfunction," he explained.
The disorder is caused by defective LDL receptors on the liver cell's surface--receptors that normally bind and take up LDL.
According to the company, Praluent inhibits the binding of PCSK9 (proprotein convertase subtilisin/kexin type 9) to the LDL receptor and thereby increases the number of available LDL receptors on the surface of liver cells, which results in lower LDL cholesterol levels in the blood.
Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice.