LDLR

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LDLR

A gene on chromosome 19p13.2 that encodes a cell surface protein involved in receptor-mediated endocytosis of low-density lipoprotein (LDL), the major cholesterol-carrying lipoprotein of plasma, which it transports into cells by endocytosis. Internalisation of the receptor-ligand complex requires clustering into clathrin-coated pits.
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With a targeted mechanism of action, bempedoic acid is a first-in-class, ATP Citrate Lyase (ACL) inhibitor that reduces cholesterol biosynthesis and lowers LDL-C by up-regulating the LDL receptor. Similar to statins, bempedoic acid also reduces hsCRP, a key marker of inflammation associated with cardiovascular disease.
Genotyping was done to detect LDL receptor gene mutation and its frequency in the studied group.
"This study examined how genetically impaired function of two proteins--the LDL receptor and lipoprotein lipase enzyme--impacts heart disease risk.
According to the companies, Praluent (alirocumab) inhibits the binding of PCSK9 to the LDL receptor and thereby increases the number of available LDL receptors on the surface of liver cells to clear LDL, which lowers LDL-C levels in the blood.
When combined in a single pill with ezetimibe, which lowers LDL by stimulating the LDL receptor, the lipid-lowering impact is magnified over that of either drug alone.
Keywords: Tissue factor, Oxidised low density lipoprotein, Lectin-like oxidised LDL receptor, Beta (2)-Glycoprotein I.
The following mouse disease models were also interrogated: LDL receptor knock-out mice, leptin receptor defective db/db mice and diet-induced obese mice.
These remnants, IDL, are cleared by the liver through apo E binding HSPG, LDL receptor-like protein (LRP) and the LDL receptor (LDLR).
(20) PCSK9 originates from hepatocytes, and it is an endogenous inhibitor of the hepatic LDL receptor. After PCSK9 binds to the LDL receptor, the LDL receptor degrades in the endosomes and lysosomes, promoting their clearance in the hepatocyte and preventing the recycling of the LDL receptor back to the cell surface, ultimately increasing plasma LDL cholesterol concentrations (21) (Figure 1a).
The LDL receptor. Arterioscler Thromb Vasc Biol 2009; 29: 431-438, doi: 10.1161/ ATVBAHA.108.179564.
[31] have shown that IL-6 decreases levels of blood lipids, increasing the expression of the LDL receptor in different tissues.
Brown, "History of discovery: the LDL receptor," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.