The study's impact was highlighted in July 2004 when the National Cholesterol Education Program revised the Adult Treatment Panel III guidelines for patients at very high risk for coronary disease, making an LDL cholesterol
goal lower than 70 mg/dL a "therapeutic option.
Wilson says he and his colleagues hope to reduce the woman's LDL cholesterol
concentration further by treating her with cholesterol-lowering drugs.
The Cornell health newsletter noted that the American Heart Association's nutrition committee recently recommended that people with high cholesterol eat three or more servings daily of soy products each containing l0 grams of soy protein per serving in order to reduce both total cholesterol levels and LDL cholesterol
High LDL cholesterol
is one of the most significant factors contributing to coronary artery disease, in which arteries supplying blood to the heart become blocked by cholesterol-filled plaques.
The primary results of that trial, first reported last April, showed that in patients with acute coronary syndrome, an aggressive regimen for lowering LDL cholesterol
using 80 mg atorvastatin/day led to fewer deaths and major cardiovascular events than did a more standard regimen of 40 mg pravastatin/day (N.
In the study, reductions of LDL cholesterol
were observed at all dosing levels, including a 16 percent reduction at a dosing level of 3.
If you have a patient with the metabolic syndrome who also has slightly elevated LDL cholesterol
, I would choose a statin as the first choice," he added.
High LDL cholesterol
levels increase the risk for heart disease.
Patients who didn't meet the NCEP ATP III goal levels for LDL cholesterol
had a 13% elevated risk of a cardiovascular event, compared with patients who met lipid goals, the researchers noted.
The results showed that patients on the diet alone reduced their LDL cholesterol
levels by an average of only five percent.
In the absence of these receptors, LDL cholesterol
builds up in the bloodstream, leading to artherosclerosis and an increased risk of heart attack or stroke.
There was no significant change in blood glucose, triglycerides, total cholesterol, or LDL cholesterol
among the placebo patients over the 60 days.