Among 25,982 FOURIER patients with a measured LDL cholesterol
level after 4 weeks on treatment and no study event as of then, 31% had their LDL cholesterol
cut to 20-49 mg/dL, 8% achieved a LDL cholesterol
level of 10-19 mg/dL, and 2% reached a remarkable LDL cholesterol
level of below 10 mg/dL, as low as herbivores such as rabbits and deer.
The trial included 501 patients with atherosclerotic cardiovascular disease (ASCVD) and elevated LDL cholesterol
(>70mg/ml) despite maximum tolerated statin therapy and patients without ASCVD but with high cardiovascular risk conditions such as diabetes and familial hypercholesterolaemia in whom LDL cholesterol
was >100mg/dl despite maximally tolerated statin therapy.
With both types of therapies, every 1 millimole per liter (39 milligrams per deciliter) reduction in LDL cholesterol
represented a 23 percent decrease in the risk of major cardiovascular events, the team reports.
If you double the dose to 20 mg, the average accompanying drop in LDL cholesterol
is about 40 percent.
In this study, we tested the hypothesis that extreme concentrations of nonfasting remnant and LDL cholesterol
are equal contributors to risk of IHD, MI, and all-cause mortality.
Eating a heart-healthy diet, exercising regularly, and losing weight if you are overweight also will bring your LDL cholesterol
level down and provide many other benefits.
But little work has addressed two important questions: (1) how often are HIV-positive people with high blood pressure or high LDL cholesterol
treated for those conditions, and (2) how often do HIV-positive people treated for high blood pressure or high LDL cholesterol
reach treatment targets?
The investigators reasoned that if low production of the LDL cholesterol
receptor in FH confers a low risk for diabetes, and if statins increase production of the LDL cholesterol
receptor, then this increase might explain the excess risk for diabetes in patients who take statins.
They were matched based upon demographics and comorbidities to an equal number of high-risk patients whose lipid-lowering regimen brought them below a target LDL cholesterol
of 100 mg/dL.
The degree of increased LDL cholesterol
in mouse studies is much higher than what is found in patients who come to the hospital with a heart attack or stroke.
The observed reductions in LDL cholesterol
are extraordinary, especially when one considers that they are seen on top of statin therapy," the paper quoted Dr Robert Giugliano, from the Brigham and Women's Hospital in Boston, Massachusetts, as saying.
If a change was made to a vegetarian or vegan diet along with eating more fiber, soy, of nuts, a 20 to 35 percent decrease in cholesterol and LDL cholesterol
levels was seen.