LD50


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Related to LD50: LC50

median lethal dose

The average amount of a drug, toxin, chemical substance/mixture or microorganism capable of killing 1/2 of the test animals exposed under specific test conditions. Median lethal dose (LD50) is commonly expressed in mg/kg, by oral intake or skin exposure.

LD50

Lethal dose50, median lethal dose The radiation dose that is lethal to 50% of those exposed–2.5-6.0 Gy, assuming that optimal care—ie transfusions, trauma and nursing care, antibiotics and nutrition—is available

LD50

In pharmacology, a dose that proves lethal to 50% of a given population.

LD50

The dose of a poison that kills half the subjects exposed to it. Used as a measure of the toxicity of drugs and other substances.

LD50

see LETHAL DOSE.

LD50

Dosage of drug or numbers of microorganisms or other pathogens that kills 50% of a test population.
References in periodicals archive ?
Each manufacturer measures the strength of their Bt product in mouse LD50 units that are not interchangeable between them (Sesardic et al., 1994).
These doses were determined from the LD50 values of the susceptible RPW population (Wadi Ad-Dawasir).
* Acute oral LD50 testing has not been routinely conducted for many years for APIs or other substances and, in any event, should not be used when other options are available;
A reduction in the length and dry mass of the seedlings was observed, with LD50 value of 19,900 mg [L.sup.-1] for those germinated in photoperiod and LD50 value of 14,700 mg [L.sup.-1] for those germinated in the dark (M-Hamvas et al., 2003).
For LD50, the selected compounds were administered intraperitoneally to mice at various doses in the multiple of [%D.sub.50] and the toxicity persuaded by them was portrayed by diminished motor activity, relaxation of muscles, failure of righting reflex, and decline level of respiration.
This study was repeated previously, with the same groups of vaccinated mice (n = 10 for all groups), except they were challenged with a lower dose (10 LD50) of Y.
naja venom (2.5x LD50, N = 20; 5 x LD50, N = 10 and 10 x LD50, N = 10) concomitantly with atropine, which blunts the muscarinic effects of neostigmine and has previously been shown to have no effect on LD50 when experimentally injected with snake venom [16].
Such a concurrent pathway decreases the bactericidal activity of AF and increases LD50 value more than twofold for the system comprising both E.
For acute toxicity study, determination of LD50, 120 animals were taken.
Intragastric introduction of pesticide Decis to the animals in a doze of 7,75 mg/kg during 60 day 3/4 LD50 under the conditions of optimum temperature caused decrease in contents of nucleic acids and protein in the subcellular fractions of the liver and mucosa of intestine.
Cytotoxicity data was fitted to a sigmoidal curve and a four-parameter nonlinear logistic model used to calculate the lethal dose of test compound that caused a 50% inhibition in comparison to untreated controls (LD50).