LD50

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Related to LD50: LC50

median lethal dose

The average amount of a drug, toxin, chemical substance/mixture or microorganism capable of killing 1/2 of the test animals exposed under specific test conditions. Median lethal dose (LD50) is commonly expressed in mg/kg, by oral intake or skin exposure.

LD₅₀

Lethal dose₅₀, median lethal dose The radiation dose that is lethal to 50% of those exposed–2.5-6.0 Gy, assuming that optimal care—ie transfusions, trauma and nursing care, antibiotics and nutrition—is available

LD₅₀

In pharmacology, a dose that proves lethal to 50% of a given population.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

LD50

The dose of a poison that kills half the subjects exposed to it. Used as a measure of the toxicity of drugs and other substances.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

LD₅₀

see LETHAL DOSE.

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

LD₅₀

Dosage of drug or numbers of microorganisms or other pathogens that kills 50% of a test population.

Medical Dictionary for the Dental Professions © Farlex 2012

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References in periodicals archive ?

Each manufacturer measures the strength of their Bt product in mouse LD50 units that are not interchangeable between them (Sesardic et al., 1994).

Botulinum Toxin Testing on Animals is Still a Europe-Wide Issue

These doses were determined from the LD50 values of the susceptible RPW population (Wadi Ad-Dawasir).

Status of Insecticide Resistance in Field-collected Populations of Rhynchophorus ferrugineus (Olivier) (Coleoptera: Curculionidae)

* Acute oral LD50 testing has not been routinely conducted for many years for APIs or other substances and, in any event, should not be used when other options are available;

Deriving health-based exposure limits in the pharmaceutical industry: a workshop was convened to advance harmonization and best practices in ADE/PDE derivation and application

A reduction in the length and dry mass of the seedlings was observed, with LD50 value of 19,900 mg [L.sup.-1] for those germinated in photoperiod and LD50 value of 14,700 mg [L.sup.-1] for those germinated in the dark (M-Hamvas et al., 2003).

Phytotoxicity associated to microcystins: a review/Fitotocixidade associada as microcistinas: uma revisao

For LD50, the selected compounds were administered intraperitoneally to mice at various doses in the multiple of [%D.sub.50] and the toxicity persuaded by them was portrayed by diminished motor activity, relaxation of muscles, failure of righting reflex, and decline level of respiration.

Preliminary anticonvulsant and toxicity screening of substituted benzylidenehydrazinyl-n-(6-substituted benzo/d/thiazol-2-yl)propanamides

This study was repeated previously, with the same groups of vaccinated mice (n = 10 for all groups), except they were challenged with a lower dose (10 LD50) of Y.

Multiple roles of Myd88 in the immune response to the plague F1-V vaccine and in protection against an aerosol challenge of Yersinia pestis CO92 in mice

naja venom (2.5x LD50, N = 20; 5 x LD50, N = 10 and 10 x LD50, N = 10) concomitantly with atropine, which blunts the muscarinic effects of neostigmine and has previously been shown to have no effect on LD50 when experimentally injected with snake venom [16].

Early treatment with intranasal neostigmine reduces mortality in a mouse model of Naja naja (Indian cobra) envenomation

Such a concurrent pathway decreases the bactericidal activity of AF and increases LD50 value more than twofold for the system comprising both E.

The activity of [60] fullerene derivatives bearing amine and carboxylic solubilizing groups against Escherichia coli: a comparative study

For acute toxicity study, determination of LD50, 120 animals were taken.

A study on the activity of Swertia chirata and Ocimum sanctum in animal model of arthritis

Intragastric introduction of pesticide Decis to the animals in a doze of 7,75 mg/kg during 60 day 3/4 LD50 under the conditions of optimum temperature caused decrease in contents of nucleic acids and protein in the subcellular fractions of the liver and mucosa of intestine.

Effect of pesticide Decis on the levels of nucleic acids and protein in the animals under condition of air high temperature, and their regulation with complex of bioactivators

(1966), allows the calculation of the confidence interval for the LD50.

Study of the toxicity of Azadirachtinon larval mortality and fertility of Carob Moth's female Ectomyeloisceratoniae (Lepidoptera, Pyralidae) under controlled conditions

Cytotoxicity data was fitted to a sigmoidal curve and a four-parameter nonlinear logistic model used to calculate the lethal dose of test compound that caused a 50% inhibition in comparison to untreated controls (LD50).

A comparative cytotoxic evaluation of acrylamide and diacetone acrylamide to investigate their suitability for holographic photopolymer formulations