Each manufacturer measures the strength of their Bt product in mouse
LD50 units that are not interchangeable between them (Sesardic et al., 1994).
These doses were determined from the
LD50 values of the susceptible RPW population (Wadi Ad-Dawasir).
* Acute oral
LD50 testing has not been routinely conducted for many years for APIs or other substances and, in any event, should not be used when other options are available;
A reduction in the length and dry mass of the seedlings was observed, with
LD50 value of 19,900 mg [L.sup.-1] for those germinated in photoperiod and
LD50 value of 14,700 mg [L.sup.-1] for those germinated in the dark (M-Hamvas et al., 2003).
For
LD50, the selected compounds were administered intraperitoneally to mice at various doses in the multiple of [%D.sub.50] and the toxicity persuaded by them was portrayed by diminished motor activity, relaxation of muscles, failure of righting reflex, and decline level of respiration.
This study was repeated previously, with the same groups of vaccinated mice (n = 10 for all groups), except they were challenged with a lower dose (10
LD50) of Y.
naja venom (2.5x
LD50, N = 20; 5 x
LD50, N = 10 and 10 x
LD50, N = 10) concomitantly with atropine, which blunts the muscarinic effects of neostigmine and has previously been shown to have no effect on
LD50 when experimentally injected with snake venom [16].
Such a concurrent pathway decreases the bactericidal activity of AF and increases
LD50 value more than twofold for the system comprising both E.
For acute toxicity study, determination of
LD50, 120 animals were taken.
Intragastric introduction of pesticide Decis to the animals in a doze of 7,75 mg/kg during 60 day 3/4
LD50 under the conditions of optimum temperature caused decrease in contents of nucleic acids and protein in the subcellular fractions of the liver and mucosa of intestine.
(1966), allows the calculation of the confidence interval for the
LD50.
Cytotoxicity data was fitted to a sigmoidal curve and a four-parameter nonlinear logistic model used to calculate the lethal dose of test compound that caused a 50% inhibition in comparison to untreated controls (
LD50).
