LHCGR(redirected from LCGR)
Also found in: Acronyms.
LHCGRA gene on chromosome 2p21 that encodes a cell surface receptor for both luteinising hormone and choriogonadotropin, which belongs to the G-protein-coupled receptor 1 family. LHCGR’s activity is mediated by adenylate cyclase-activating G proteins.
LHCGR mutations cause a range of disorders affecting male secondary sexual development, such as familial male precocious puberty (testotoxicosis), hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty and male pseudohermaphtoditism with Leydig cell hypoplasia.