ERBB3

(redirected from LCCS2)

ERBB3

A gene on chromosome 12q13 that encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases which binds and is activated by neuregulins and NTAK.

Molecular pathology
ERBB3 amplification and overexpression has been described in multiple cancers, including prostate, bladder and breast.
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References in periodicals archive ?
Lethal congenital contracture syndrome 2 (LCCS2) also includes cranial and ocular abnormalities and striking enlargement of the bladder accompanied by hydronephrosis and cystic changes of the kidneys.
Birk, "Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the phosphatidylinositol-3-kinase/Akt pathway," American Journal of Human Genetics, vol.
Lethal congenital Antenatal Congenital ERBB3 contracture contractures, syndrome 2 dysmorphism, and (LCCS2) urinary bladder involvement.