3] amounts and composition, as well as LCAT
activity, in rat fed a cholesterol-rich diet (1%).
063 Electrophoresis broad[beta] [beta] Apoproteins B100, E B100 Core lipid (mass) TG=CE CE [much greater than] TG Subspeciation Large (A) Small (B) Modulation HL, CETP LCAT
, HL, CETP Receptors LRP, LDLR LDLR Cholesterol 0 3 concentration--in fasting (mmol/l) Lipoproteins HDL Size (nm) 3-12 Density (g/ml) 1.
was assayed by measuring the rate of esterification using cholesterol labeled with radioactive carbon ([sup.
deficiency is a rare, inherited condition that causes lipid accumulation in the eyes, red blood cells and kidneys.
is the key enzyme in mediating the esterification of cholesterol on circulating lipoproteins.
Increased catabolism of LpAI and LpAI:AII leading to low HDL cholesterol concentrations is characteristic of Tangier disease and LCAT
The increase in HDL cholesterol after administration of ACP-501 supports the notion that LCAT
is a bottleneck in the reverse cholesterol transport process," noted Auerbach.
d) Dose TC (a) TG (a) PL (a) LCAT
PHLA (mg/kg) (b) [c] AE 100 -8.
1] HDL concentration and LCAT
activity, were found to be associated with IHD in individuals with both low and high HDL-C.
Additionally, ACP-501 is being developed to treat familial LCAT
deficiency (an orphan designated enzyme replacement therapy) and other diseases where LCAT
activity is low.
Several patients with a genetic disorder in lipid metabolism, such as LCAT
deficiency, had direct-method results that differed so markedly from the RMPs and from the typical values seen in these kinds of patients with HDL-C precipitation-based methods and a calculated LDL-C that they could have been misdiagnosed.
AlphaCore Pharma, a biopharmaceutical company, and Advanced Bioscience Laboratories (ABL), a biomedical contract research and manufacturing company, today announce funding from the National Institutes of Health, National Heart, Lung and Blood Institute (NHLBI) "Science Moving towards Research Translation and Therapy" (SMARTT) program, to manufacture recombinant human lecithin-cholesterol acyltransferase (rhLCAT) for the treatment of familial LCAT