CDH1

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CDH1

A gene on chromosome 16q22.1 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells.

Molecular pathology
CDH1 loss-of-function mutations correlate with gastric, breast, colorectal, thyroid and ovarian cancer, and they are thought to contribute to cancer progression by increasing proliferation, invasion and/or metastasis. CDH1 mutation causes hereditary diffuse gastric cancer and an increased susceptibility to endometrial and ovarian cancers.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
In LCAM 1E, the dew-point temperature at the peak dry-bulb temperature and mean coincident wet-bulb temperature was assumed to prevail through the day unless the dry-bulb temperature fell below the dew point.
LCAM 1E presented the same clear-sky solar radiation model that had been presented in ASHRAE Handbook-Fundamentals since 1967.
In LCAM 1E, IACs were tabulated for different combinations of glazing and interior shade types.
LCAM 1E contains data from the 2005 ASHRAE Handbook-Fundamentals and LCAM 2E contains data from the 2013 ASHRAE Handbook-Fundamentals.
* ASHRAE Technical Committee 4.4, Building Materials and Building Envelope Performance, made a major revision of the building thermal properties data in the 2013 ASHRAE Handbook-Fundamentals, and this new data set has been incorporated into LCAM 2E.
Therefore, a single building zone--the corner office used as an example in LCAM 2E--was selected as the base case.
For the international locations, a clearness number of 1 was used with the LCAM 1E solar model.
LCAM 2E: new solar model, new climate data, new daily profiles
LCAM 2E-OSM: old solar model, new climate data, new daily profiles
LCAM 1E: old solar model, old climate data, old daily profiles