ACADL

(redirected from LCAD)
Also found in: Acronyms.

ACADL

A gene on chromosome 2q34-q35 that encodes an acyl-CoA dehydrogenase which is a mitochondrial flavoenzyme involved in fatty acid and branched chain amino-acid metabolism. It is one of four enzymes that catalyse the first step of mitochondrial beta-oxidation of straight-chain fatty acid.

Molecular pathology
Defects of ACADL cause long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycaemia.
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References in periodicals archive ?
The downregulation of UCPs and SIRT3 and the hyperacetylation of LCAD (long chain acyl-CoA dehydrogenase) and [beta]-HAD ([beta]-hydroxyacyl-CoA dehydrogenase) lead to the accumulation of LCFA-CoA.
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In January 2002, six more tests were added for the fatty acid oxidation disorders (MCAD, SCAD, LCAD and VLCAD) and two urea cycle disorders, arginosuccinic acidemia and citrullinemia.
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She runs LCAD, the Liverpool Centre For Arts Development, and at the end of a long and boozy meeting on Hope Street, she'd enrolled me on an NVQ course that's called, excitingly, ' Creative Entrepreneurs'.
Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD)--LCAD in infants is typified by failure to thrive, enlarged liver, enlarged heart, metabolic encephalopathy, and hypotonia.
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