BCL6

(redirected from LAZ3)

BCL6

A gene on chromosome 3q27 that encodes a zinc finger transcription factor that acts as a sequence-specific repressor of transcription. BCL6 modulates the transcription of START-dependent IL-4 responses of B cells, and interacts with various POZ-containing transcription co-repressors.

Molecular pathology
BCL6 is often translocated (e.g., t(3;14)(q27;q32); t(3;22)(q27;q11)) and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in DLCL pathogenesis.
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Analysis of LAZ3 (BCL-6) status in Bcell non-Hodgkin's lymphomas: results of rearrangement and gene expression studies and a mutational analysis of coding region sequences.
Over the last several years, novel rearrangements have been reported for the bcl-2 (33) and LAZ3 (BCL6) genes (34) in patients with follicular lymphoma, unusual bcr/abl fusion transcripts (e8/a2 and e13/a2) have been reported in patients with Philadelphia chromosome-positive leukemia (35), and B- or T-cell gene rearrangements have been reported in patients with intraocular lymphoma (36).