CXCR4

(redirected from LAP3)

CXCR4

A gene on chromosome 2q21 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which binds specifically to stromal cell-derived factor-1, transducing a signal by increasing intracellular calcium ions and enhancing MAPK1/MAPK3 activation. It acts as a receptor for extracellular ubiquitin, is involved in haematopoiesis and in cardiac ventricular septum formation, plays a role in gastrointestinal tract vascularisation by regulating vascular branching and/or remodelling in endothelial cells, may be involved in cerebellar development and, in the CNS, may mediate hippocampal-neuron survival.

Molecular pathology
CXCR4 acts with the CD4 to support HIV entry into cells; it is highly expressed in breast cancer cells. CXCR4 mutations cause WHIM (warts, hypogammaglobulinaemia, infections, and myelokathexis) syndrome.
References in periodicals archive ?
On chromosome 6 there are several protein coding sequences in near vicinity of the locus rs109210955, including leucine aminopeptidase (LAP3), mediator of RNA polymerase II transcription subunit 28 (MED28), family with sequence similarity 184 member B (FAM184B), DDB1 and CUL4 associated factor 16 (DCAF16), non-SMC condensin I complex subunit G (NCAPG), ligand-dependent nuclear receptor corepressor-like protein (LCORL).
This highly differentiated, polarized and in vivo like phenotype of the 3D model was further supported by the enhanced expression of brush border markers, e.g., glutamyltransferase 1 (GGT1), leucine aminopeptidase (LAP3) and alkaline phosphatase (ALPL) when compared to cells cultured under simpler conditions (Fig.
Preuss et al., "LAP3, a novel plant protein required for pollen development, is essential for proper exine formation," Sexual Plant Reproduction, vol.
(1) School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of Health, (2) Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), and (3) Zhongshan Hospital, Fudan University, Shanghai, China; 4Department of Epidemiology and Biostatistics, and 5Department of Public Health Studies, Texas A&M School of Public Health, College Station, Texas, USA
The reduced palmitate trait in the lines was controlled by the fap1 and lap3 alleles (Fehr et al., 1991).
4 to 79.5 Mb), including seven significant SNPs and four candidate genes ligand dependent nuclear receptor corepressor-like (LCORL), leucine aminopeptidase 3 (LAP3), LDB2, transmembrane anterior posterior transformation 1 (TAPT1), were found to have association with carcass weight and eviscerated weight (Liu et al., 2013).
[1] School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China; [2] Research Institute for the Changing Global Environment and Fudan Tyndall Centre, Fudan University, Shanghai, China; [3] Shenyang Institute of Atmospheric Environment, China Meteorological Administration, Shenyang, China; [4] Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Fudan University, Shanghai, China
The [F.sub.2:3] lines were assumed to have the genotype fap1 fap1 lap3 fap3 fan1(A5) fan1(AS) fan2 fan2 based on their contents of palmitate and linolenate.
Further characterization of these haplotypes using sequence information, radiation hybrid mapping and comparative mapping with the human genome sequence resolved the QTL to a 420Kb haplotype region between gene ABCG2 and LAP3 (Olsen et al., 2005).
Expected [F.sub.3] segregation [F.sub.2] genotype =P1([dagger]) >P1 to <P2 =P2 fap3 fap3 Fap5 Fap5 X fap3 fap3 Fap5 fap5 or Fap3 fap3 Fap5 Fap5 X X fap3 lap3 fap5 fap5 or Fap3 Fap3 Fap5 Fap5 X Fap3 fap3 Fap5 fap5 X X X Fap3 fap3 fap5 fap5 or Fap3 Fap3 Fap5 fap5 X X Fap3 Fap3 fap5 fap5 X [F.sub.2] plants [F.sub.2] genotype Expected Observed([double dagger]) -- no.