LAMA5

LAMA5

A gene on chromosome 20q13.2-q13.3 that encodes laminin alpha 5, an extracellular matrix protein found in laminin and a major component of basement membranes.
References in periodicals archive ?
No human diseases have been associated with mutations in LAMA1, LAMA5, and LAMC1 (encodes laminin [gamma]1) to date, although lama1, lama5, lamb1, and lamc1 null mice are embryonic lethal [24, 45, 46], while a hypomorphic allele of lamal results in retinal defects in mice [47], point mutations in LAMB1 result in lissencephaly-5 in humans [ 48], and mutations of LAMB2 result in Pierson syndrome [49], which causes severe nephrosis and ocular abnormalities including lens malformations and cataracts demonstrating the critical role that these laminins play in development.
The laminin composition of the zebrafish corneal BM has not been reported; however, in humans, lama3 and lama5 are found to be the predominant laminin a chains in the BM underlying the adult corneal epithelium, while lama1 was not detected [22].