LAMA1


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LAMA1

A gene on chromosome 18p11.3 that encodes laminin alpha 1, an extracellular matrix (ECM) protein that mediates the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other ECM components (e.g., fibulin-2, which is encoded by FBLN2).
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The transcripts of FGF-4, IL-6 and LAMA1 genes were detected in day 7 blastocyst originating from oocytes matured in different groups.
Fibroblast growth factor-4 (FGF4), Laminin [alpha]1 (LAMA1) and Interleukin-6 (IL6) genes are known to have specific functions through early embryo development (Desai et al., 1999; Hallmann et al., 2005; Sanna, 2009; Valdez-Magana et al., 2014).
At this concentration, the sheep follicular fluid modulated genes related to apoptosis and stress whereas exerted no effect on the genes of FGF-4, IL-6 and LAMA1.
Genes implicated in the development of pathological myopathy include collagen type I (COL1A1), laminin alpha 1 (LAMA1), luminal (LUM), transforming growth factor beta 1 (TGFB1), paired box 6 (PAX6), insulin-like growth factor-1 (IGF1), zinc finger 644 (ZNF644), fibroblast growth factor 10 (FGF10), transforming growth factor beta-induced factor 1 (TGIF1), uromodulin-like 1 (UMODL1), and catenin delta-2 (CTNND2).5-15
Numerous studies have investigated the role of TGFB1 and LAMA1, which are involved in the restructuring of scleral collagen and proteoglycans, in myopia.
The LAMA1 gene has received the most attention among those thought to be involved in high myopia.
LAMA1 protein expression was assessed by Western blotting.
LAMA1 mRNA expression in glucose-treated RF/6A cells was detected by real-time PCR.
Effects of High Glucose on LAMA1 Expression in RF/ 6A Cells
The laminin composition of the zebrafish corneal BM has not been reported; however, in humans, lama3 and lama5 are found to be the predominant laminin a chains in the BM underlying the adult corneal epithelium, while lama1 was not detected [22].
Our data demonstrate that lama1 is essential for the formation of the lens capsule including the deposition of collagen IV into the capsule and thus lens morphology/structure.