LIPA

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LIPA

A gene on chromosome 10q23.2 that encodes lipase A, the lysosomal acid lipase (i.e., cholesterol ester hydrolase) that catalyses the hydrolysis of cholesteryl esters and triglycerides in lysosomes.

Molecular pathology
LIPA mutations are linked to CESD and Wolman disease.
References in periodicals archive ?
CP: Could tightening supplies of LAL, and a dwindling crab population, be a factor in the future?
In addition, the rapid LAL testing method uses one-twentieth the amount of LAL that the original test did.
Synageva cannot be sure if its Phase 3 trial design will allow it to sufficiently assess the effects of sebelipase alfa on a broad range of abnormalities associated with LAL Deficiency nor can it be sure that it will be able to enroll its target number of patients in the Phase 3 trial.
The publication of these data in Hepatology underscores the ability of sebelipase alfa to reduce markers of liver damage and improve dyslipidemia in these adults with LAL Deficiency," said Anthony Quinn, MBChB, PhD, FRCP, Senior Vice President and Chief Medical Officer of Synageva BioPharma.
Sebelipase alfa (formerly referred to as SBC-102) is a recombinant form of the human LAL enzyme under development by Synageva as an enzyme replacement therapy for LAL Deficiency, a lysosomal storage disorder (LSD).
Six of the samples (previously reported on January 20th and February 9th 2005) LAL 232, 234, and 236 were collected to be specifically representative of the xenolithic material (oblong footballshaped masses of mica and actinolite), while samples LAL 233, 235 and 237 consist mostly of the finegrained hostrock matrix surrounding the xenoliths.
The remaining 2 samples from the fall campaign (LAL 231 and LAL 238) were sampled to test extensions of the observed geological unit, as were the final ten samples reported in the table above.
The diamond results from this particular outcrop area are similar to the range of the diamond count values of samples LAL 221 to LAL 230.
Six of the samples LAL232, 234, and 236 were collected to be specifically representative of the xenolithic material (oblong football shaped masses of mica and actinolite), while samples LAL 233, 235 and 237 consist mostly of the fine grained host rock matrix hosting the xenoliths.
These large samples were selected from two nearby sites (LAL 221 and LAL 223) are being processed by Lakefield Research's diamond recovery laboratory in Lakefield Ontario.
NYSE: EL) announced today that it has agreed with the trustee of The Estee Lauder 1994 Trust and the trustees of the LAL 1995 Preferred Stock Trust to exchange all $360 million of their outstanding shares of $6.