AFF3

(redirected from LAF4)

AFF3

A gene on chromosome 2q11.2-q12 that encodes a tissue-restricted nuclear transcriptional activator preferentially expressed in lymphoid tissue, which may function in lymphoid development and oncogenesis.

Molecular pathology
In some ALL patients, AFF3 is fused to the gene for MLL.
References in periodicals archive ?
The AFF gene family consists of AFF1 [also known as ALL1-fused gene from chromosome 4 (AF4)], AFF2 [also known as fragile X mental retardation 2 (FMR2)], AFF3 [also known as lymphoid nuclear protein related to AF4 (LAF4)], and AFF4 [also known as ALL1-fused gene from 5q31 (AF5q31) or major CDK9 elongation factor associated-protein (MCEF)] (21).