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Related to L-selectin: E-selectin


A gene on chromosome 1q23-q25 that encodes l-selectin, a cell surface adhesion/homing receptor required for binding and rolling of leukocytes on endothelial cells, facilitating leukocyte migration into secondary lymphoid organs and inflammation sites. 

Molecular pathology
SELL polymorphisms are associated with various diseases, including IgA nephropathy.


An adhesion molecule that triggers off the interaction between leukocytes and blood vessel endothelium. It is shed from the surface membrane of haematopoietic cells and circulates in the blood as a functional receptor.
References in periodicals archive ?
These cells character istically express high levels of L-selectin and CCR7, which they use to interact with HEV ECs, just like naive T cells do.
The team will also be looking to identify which molecule L-selectin binds to in virus infected tissues that allows killer T cells to be directed there.
2- To investigate whether serine phosphorylation of L-selectin tail regulates interaction with binding partners and L-selectin functions in vitro;
Effects of age and nutrition on expression of CD25, CD44 and L-selectin (CD62L) on T cells from neonatal calves.
Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow.
A dual-binding antibody to E- and l-selectin attenuates sepsis-induced lung injury.
These results suggest that L-selectin mediates interactions with the uterus and that this adhesion mechanism may be critical to establishing human pregnancy," Fisher said, according to the Times.
When these immune cells are called into action, L-selectin and related molecules bind to carbohydrates on the inside surface of a blood vessel.
The scientists commented that the mobilization of stem cells treated by an L-selectin blocker appears to be of a lower magnitude and greater transience of effects than can be achieved by the administration of granulocyte colony-stimulating factor (G-CSF).
A hematopoietic cell L-selectin ligand that is distinct from PSGL-1 and displays N-glycan-dependent binding activity.
Biological determinants of serum sICAM-1, E-selectin, P-selectin and L-selectin levels in healthy subjects: the Stanislas study.