l-dopa


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Related to l-dopa: levodopa, dopamine, Mucuna pruriens

dopa

 [do´pah]
a compound produced by oxidation of tyrosine by tyrosinase; it is the precursor of dopamine and an intermediate product in the biosynthesis of norepinephrine, epinephrine, and melanin. The naturally occurring form is l-dopa (see levodopa), and is used to treat parkinson's disease and other forms of parkinsonism.

le·vo·do·pa

(lē'vō-dō'pă),
The biologically active form of dopa; an antiparkinsonian agent that is converted to dopamine.
Synonym(s): l-dopa

l-dopa

levodopa.

L-dopa

(ĕl-dō′pə)
n.
An isomer of dopa that is converted in the brain to dopamine and is used in synthetic form to treat Parkinson's disease. Also called levodopa.

l-dopa

See levodopa.

l-dopa

Abbreviation for levodopa.

Levodopa (L-dopa)

A substance used in the treatment of Parkinson's disease. Levodopa can cross the blood-brain barrier that protects the brain. Once in the brain, it is converted to dopamine and thus can replace the dopamine lost in Parkinson's disease.
Mentioned in: Movement Disorders

laevodopa

; levodopa; L-dopa biologically active form of dopamine (used to control symptoms of Parkinson's disease)

levodopa, L-DOPA

the pharmaceutical name for dopa.
References in periodicals archive ?
Among the central dopaminergic side effects of L-dopa, hallucinations and psychotic symptoms can cause important problems.
During L-DOPA treatment, body weights were recorded weekly till the end of the experiment for all the groups.
L-Tyrosine and L-dopa quickly decompose to some other metabolites such as dopamine and dopachrome.
Development of GID has been proposed to be caused by several different mechanisms, such as extent of DA neuron degeneration [27], excessive DA release from the graft, graft size, graft placement [28-32], age [33], pretreatment with L-DOPA, severity of preoperative LID [32, 34, 35], or immunosuppression [23, 36, 37].
Irreversible L-dopa dyskinesias do not exist; they are a function of carbidopa which has a profound ability to induce previously undocumented histamine dyskinesias.
Como medida preventiva ao aparecimento das complicacoes motoras decorrentes do uso prolongado da L-DOPA, especialmente nas fases mais avancadas da doenca, o metodo de escolha tem sido a utilizacao conjunta desta com agonistas dopaminergicos [5,7], dentre os quais podem ser elencados anticolinergicos, antiglutamatergicos e inibidores da monoamino oxidase (MAO) [7].
Metabolites 1 L-Dopa 2 5'-Methylthioadenosine 3 Tetradecanoylcarnitine 4 Phytosphingosine-l-P 5 Cer(d18:0/18:0) 6 LysoPC(20:4(5Z,8Z,11Z,14Z)) 7 L-Palmitoylcarnitine 8 Tetracosanoylglycine 9 Morphiceptin 10 Stearoylcarnitine
While no other treatment approaches L-DOPA for efficacy, it is associated with troubling motor adverse effects in the majority of patients using it long term.
These remarkable clips of Sacks also include his memories of his ground-breaking work with patients which led him to write Awakenings: "I gave L-DOPA in March of '69 to three patients, and a placebo to three other patients.
The change of acidity in the gel upon UV irradiation caused L-DOPA to be released because the acidity disrupted the interaction of L-DOPA with the molecules in the gel.
One trial compared L-dopa with propoxyphene and placebo, and the other compared it with pergolide, a bromocriptine agonist available in Canada and Europe.