carnosine

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carnosine

 [kahr´no-sēn]
a dipeptide composed of beta-alanine and histidine, found in skeletal muscle of vertebrates.

car·no·sine

(kar'nō-sēn),
N-β-alanyl-l-histidine; the dominant nonprotein nitrogenous component of brain tissue, first found in relatively high amounts in muscle; chelates copper and activates myosin ATPase.
Synonym(s): ignotine, inhibitine
[L. carnosus, fleshy, fr. caro, flesh, + -ia]

carnosine

A dipeptide composed of beta-alanine and histidine that is concentrated in skeletal muscle and the brain. While its function is unknown, carnosine has antioxidant properties, counteracts glycation, chelates divalent metal ions and acts as a buffer, stabilising the pH of anaerobically contracting muscle.
References in periodicals archive ?
Characterization of crystalline L-carnosine Zn(II) complex (Z- 103), a novel anti-gastric ulcer agent: tautomeric change of imidazole moiety upon complexation.
Acceleration of metabolism of stress-related substances by L-carnosine. Nihon Seirigaku Zasshi.
Additive Concentration Acetovanillone 50 [micro]M Adenosine 5 mM Allopurinol 1 mM Antimycin A 20 nM Aspirin (acetylsalicylic acid) 133-400 [micro]g/ml ATP (adenosine triphosphate) 67-200 [micro]M Dimethyl (S)-(-)-malate 2,5 mM DMSO (dimethyl sulfoxide) 0.07-0.20% Fenoldopam mesylate 6.7-20 [micro]M L-Gluthatione 3 mM Glycerol 7.5-100 mg/ml Hydrocortizone 3 ng/ml Icilin 0.33-1 [micro]M Insulin 5 [micro]g/ml Lactic acid 13-40 mM L-Ascorbic acid 50 [micro]g/ml L-carnosine 13.3-40 mM Leukemia inhibitory factor (LIF) 13-40 ng/ml LiCl 1 mM Melatonin 0.67-2 nM Menthol 16.7-50 [micro]M Methyl pyruvate 1 mM N-(2-Mercaptopropionyl)glycine (NMPG) 100 [micro]M N-Acetyl-L-cysteine 1 mM Sodium pyruvate 10mM Taurine 20mM Additive Supplier Acetovanillone Sigma-Aldrich (St.
Comment: L-carnosine (beta-alanyl-L-histidine) occurs naturally in the body.
Addition of L-carnosine in cardioplegic solution during stopped heart operations allows increasing the operation duration severalfold without signs of necrotic damage of tissues of the heart in the operative field [45].
(4,6) L-carnosine (beta-alanyl-L-histidine) is the synthetic version identical to the natural form alpha-alanyl-L-histidine.
L-carnosine ([beta]-alanyl-L-histidine, LC) is a dipeptide made up of [beta]-alanine and L-histidine, which is highly concentrated in muscle and brain tissues of animals.
Identification and characterization of a mouse dipeptidase that hydrolyzes L-carnosine. Journal of Biochemistry.
Hereafter the cells were challenged for 24 h with different concentrations of Fe[Cl.sub.3] (Sigma, Munich, Germany) or Zn[Cl.sub.2] (Sigma, Munich, Germany) either in the presence or in the absence of L-carnosine (Sigma, Munich, Germany).
L-Carnosine - Protects from oxidation and free radical damage.
Zinc L-carnosine protects against mucosal injury in portal hypertensive gastropathy through induction of heat shock protein 72.
A newly formulated combination of zinc and L-carnosine (a combination of two amino acids) does all of these.