L-SOX5 | definition of L-SOX5 by Medical dictionary
SOX5 (redirected from L-SOX5)
SOX5 A gene on chromosome 12p12.1 that encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which regulate embryonic development and determine cell fate. SOX5 may act as a transcription regulator after forming a complex with other proteins and may play a role in chondrogenesis.
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References in periodicals archive
A new long form of Sox5 (L-Sox5
), Sox6 and Sox9 are co-expressed in chondrogenesis and cooperatively activate the type II collagen gene.
Chano et al., "Identification and characterization of the human long form of Sox5 (L-SOX5
) gene," Gene, vol.
Mandel et al., "The transcription factors L-Sox5 and Sox6 are essential for cartilage formation," Developmental Cell, vol.
Lefebvre, "L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer," Molecular and Cellular Biology, vol.
Kato et al., "L-Sox5
and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity," Journal of Biological Chemistry, vol.